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CLINICAL TRIALS

As the breadth of PH research expands, PHA is committed to keeping its members informed about ongoing clinical research pertaining to evaluation and treatment of pulmonary hypertension. One mechanism to achieve this is to provide institutions and other research sponsors who are conducting multi-center clinical trials with an opportunity to describe relevant studies.

PH Clinical Trials

Trial Name: A multicenter, double-blind, randomized, placebo-controlled, Phase 3 study to assess the efficacy and safety of oral BPS-314d-MR added on to treprostinil, inhaled (Tyvaso) in subjects with pulmonary hypertension
Sponsoring Institution: Lung Biotechnology, PBC
Posted August 15, 2016
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Trial Name: IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients
Sponsoring Institution: Imperial College London
Posted August 15, 2016
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Trial Name: A Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1) (LIBERTY)
Sponsoring Institution: Eiger BioPharmaceuticals, Inc.
Posted June 10, 2016
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Trial Name: Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAH (INOvation-1)
Sponsoring Institution: Bellerophon Therapeutics
Posted June 9, 2016
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Trial Name: Bardoxolone Methyl Evaluation in Patients With Pulmonary Arterial Hypertension (PAH) - LARIAT
Sponsoring Institution: Reata Pharmaceuticals
Posted Aug. 18, 2015
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Trial Name: A Randomized, Double-blind, Parallel-group, Placebo-controlled Phase 2 Trial of APD811, an Oral IP Receptor Agonist, in Patients with Pulmonary Arterial Hypertension
Sponsoring Institution: Arena Pharmaceuticals, Inc.
Posted Aug. 18, 2015
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Trial Name: A multi-center, double-blind, randomized, placebo-controlled, Phase 3 study to assess the efficacy and safety of oral BPS-314d-MR added-on to treprostinil, inhaled (Tyvaso) in subjects with pulmonary arterial hypertension
Sponsoring Institution: Lung Biotechnology Inc. (subsidiary of United Therapeutics)
Posted April 19, 2014
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Trial Name: Trial of the Early Combination of Oral Treprostinil With a PDE-5 Inhibitor or ERA in Subjects wth Pulmonary Arterial Hypertension
Sponsoring Institution: United Theraputics Corporation
Posted August 27, 2013
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Trial Name: A Natural History Study of Novel Biomarkers in Pulmonary Arterial Hypertension
Sponsoring Institution: National Institutes of Health
Posted January 22, 2013
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Trial Name: A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial Hypertension
Sponsoring Institution: National Institutes of Health
Posted January 22, 2013
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Trial Name: A Multiple Ascending Dose Study of Tadalafil to Assess the Pharmacokinetics and Safety in a Pediatric Population with Pulmonary Arterial Hypertension
Sponsoring Institution: Eli Lilly and Company
Posted July 6, 2012
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Trial Name: Determining the Prevalence and Progression of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell Anemia
Sponsoring Institution:
National Heart, Lung, and Blood Institute (NHLBI)
Posted December 15, 2011
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Trial Name: A Randomized, Double-Blind, Placebo-Controlled, Phase II Multicenter Trial of a Monoclonal Antibody to CD20 (Rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH).
Sponsoring Institution: National Institute of Allergy and Infectious Diseases (NIAID)
Posted December 16, 2010
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