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Autumn 2004, Vol. 3, No. 3

Editor’s Memo   PHA Scientific Sessions Break New Ground, Providing Timely, Focused Venue for Current Research This issue of Advances in Pulmonary Hypertensionis the next best thing to being there—attending the first Scientific Sessions of the Pulmonary Hypertension Association, held from June 24 to 26 in Miami, in conjunction with PHA’s 6th International Conference. The reports from presenters will give you a sense of the excitement attendees shared in being a part of this effort to break new ground by establishing a PH focus for results of current research. Until this meeting was held, physicians seeking such information had to look toward multiple meetings where research findings were presented, including large cardiology and pulmonology conferences, sporadic symposia, and a number of smaller conferences. Few, if any, of these meetings were dedicated to PH research per se. Because few physicians are able to attend all of these meetings pertaining to PH, the 2004 PHA Scientific Sessions were intended as the first of a series of conferences consolidating PH-related information and allowing professionals to network with others sharing a similar interest. The sessions also focused on another objective—presenting viewpoints of those working primarily in fields outside of PH, such as cancer and genetics. The coverage in this issue provides a representative sample of new directions in PH research from those who presented this information during the Scientific Sessions. A total of 47 abstracts were presented, 5 orally and the rest as posters. These abstracts covered the gamut of PH research, including clinical drug studies, patient demographics, hemodynamic monitoring, treatment strategies, and basic studies of the molecular processes and cell biology of PH. The Scientific Sessions proved to be a valuable addition to the well-established International PHA Conference. The financial support provided by the National Heart, Lung, and Blood Institute, the Centers for Disease Control and Prevention, the Office of Rare Diseases, and healthcare sponsors assured a forum for the productive exchange of information. Looking ahead, the next Scientific Sessions will be held in Minneapolis in 2006; you may want to make early note of a meeting that should not be missed. Michael McGoon, MD Guest Editor   Take it With You   Download this issue in PDF (2 MB)   Issue Sponsor Ads   Actelion (PDF) Accredo Therapeutics(PDF)   PHA Announcements   PH Doctor: A new professional section within PHA for physicians and MD/PhD-level researchers interested in pulmonary hypertension (PDF) (HTML) New PH Practice Guidelines from the ACCP (PDF) (HTML) November is PH Awareness Month / 2005 Postdoctoral Fellowship Awards Application Process (PDF)	Articles   Advances in Pulmonary Hypertension, Autumn 2004, Vol. 3, No. 3 cover close-up Click titles to read stories... Profiles in Pulmonary Hypertension: Robyn J. Barst, MD: Juggling Roles of Patient Advocate and Director of a Leading Research Center, Robyn Barst Meets the Challenge Great clinicians often distinguish themselves by fulfilling several demanding roles at the same time, by not only establishing their reputation as preeminent caregivers but also leading their colleagues toward excellence in other ways—for instance, in patient advocacy and establishment of referral centers. A case in point is Robyn J. Barst, MD. ... Exploring the Role of BMPR2 as Key Genetic Marker in Pulmonary Vascular Disease The genetics of pulmonary arterial hypertension is a rapidly growing investigative area that has witnessed significant advances in the past few years. A heritable form of pulmonary hypertension, familial primary pulmonary hypertension, was first recognized in 1948. In the general population the incidence of primary pulmonary hypertension ranges from 1 to 2 cases per million, and its pattern of inheritance is autosomal dominant with incomplete penetrance.... Why Potassium Channel Dysfunction May Be ‘Missing Link’ in Pathophysiology of PAH Potassium (K+) channel dysregulation in pulmonary artery smooth muscle cells (PASMCs) is important in understanding the etiology of pulmonary arterial hypertension (PAH), which is characterized by abnormalities in the vascular biology of the pulmonary circulation at all levels from lumen to adventitia.... Medical Treatment Options/Advances in Portopulmonary Hypertension: How the Spectrum Is Expanding Part 2 from previous issue's coverage: Portopulmonary hypertension is defined as the presence of an elevated pulmonary artery pressure (PAP; resting mean PAP >25 mm Hg or exercise PAP >30 mm Hg), with a normal pulmonary capillary wedge pressure in the presence of portal hypertension.... Pulmonary Hypertension Roundtable Recapping Highlights from Pulmonary Hypertension Association Scientific Sessions and Identifying Key Issues Driving Translational Research Featuring: Michael McGoon, MD Professor of Medicine and Consultant in the Division of Cardiovascular Diseases and Internal Medicine Mayo Clinic College of Medicine Rochester, Minnesota Victor F. Tapson, MD Professor of Medicine Division of Pulmonary and Critical Care Medicine Duke University Medical Center Durham, North Carolina Richard N. Channick, MD Associate Professor of Medicine Pulmonary and Critical Care Division University of California, San Diego Medical Center San Diego, California Vallerie V. McLaughlin, MD Associate Professor of Medicine Director, Pulmonary Hypertension Program University of Michigan Health System Ann Arbor, Michigan Ronald J. Oudiz, MD Associate Professor of Medicine UCLA School of Medicine Director, Liu Center for Pulmonary Hypertension, Division of Cardiology Harbor- UCLA Medical Center Torrance, California Ivan M. Robbins, MD Director, Pulmonary Hypertension Center Vanderbilt University Nashville, Tennessee
Notes   Editorial Advisory Board Editor-in-Chief Richard Channick, MD Professor of Clinical Medicine Pulmonary and Critical Care Division University of California, San Diego Medical Center San Diego, California Immediate Past Editor Ronald J. Oudiz, MD Associate Professor of Medicine The David Geffen School of Medicine at UCLA Director, Liu Center for Pulmonary Hypertension LA Biomedical Research Institute at Harbor-UCLA Medical Center Editor-in-Chief Elect Erika Berman Rosenzweig, MD Director, Pulmonary Hypertension Center, Columbia University Medical Center Associate Professor of Clinical Pediatrics (in Medicine) Associate Editors Kristin Highland, MD Assistant Professor of Medicine Division of Pulmonary, Critical Care, Allergy and Sleep Medicine Medical University Of Carolina Francisco Soto, MD, MS Director, Pulmonary Hypertension Program Pulmonary and Critical Care Medicine Medical College of Wisconsin Todd Bull, MD Associate Professor of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Robert Schilz, DO, PhD Medical Director of Lung Transplantation and Pulmonary Vascular Disease University Hospital of Cleveland Case Western Reserve University Cleveland, Ohio Publisher Pulmonary Hypertension Association Carl Hicks, Board Chair Rino Aldrighetti, President Sherrie Borden, Vice President, Medical and Patient Education Publishing Staff Managing Editor Deborah L. McBride McBride Strategic Services mcbridedeb@aol.com P: 773-348-5455 C: 312-307-5455 Design Director Michael McClain PHA Office Pulmonary Hypertension Association 801 Roeder Road, Ste. 400 Silver Spring, MD 20910 301-565-3004, 301-565-3994 (fax) www.PHAssociation.org © 2009 by Pulmonary Hypertension Association. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA. Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association. The contents of the articles are independently determined by the Editor and the Editorial Advisory Board. PHA's Scientific Leadership Council Editorial Mission Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association. Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.   Editorial Board Charles Burger, MD Medical Director, PH Clinic Mayo Clinic Jacksonville, FL Karen Fagan, M.D. Chief, Division of Pulmonary and Critical Care Medicine University of South Alabama Eli Gabbay, MD Lung Transplant Unit Royal Perth Hospital Nick Kim, M.D. Associate Clinical Professor of Medicine University of California San Diego Deborah Jo Levine, M.D. University of Texas Health Science Center at San Antonio San Antonio, TX Omar Minai, MD Dept of Pulmonary, Allergy  and Critical Care Medicine Myung Park, MD Associate Professor of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Fernando Torres, MD Director Pulmonary Hypertension Clinic UTSW Medical Center Dallas University Hospital Glenna Traiger, RN, MSN Pulmonary & Critical Care Pulmonary Hypertension CNS University of California Los Angeles Los Angeles, CA R. James White, MD, PhD Assistant Professor of Medicine, Pharmacology & Physiology University of Rochester, Division of Pulmonary and CCM Roham Zamanian, MD Division of Pulmonary and Critical Care Medicine Stanford University Medical Center

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