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Autumn 2004, Vol. 3, No. 3

Editor’s Memo   PHA Scientific Sessions Break New Ground, Providing Timely, Focused Venue for Current Research This issue of Advances in Pulmonary Hypertensionis the next best thing to being there—attending the first Scientific Sessions of the Pulmonary Hypertension Association, held from June 24 to 26 in Miami, in conjunction with PHA’s 6th International Conference. The reports from presenters will give you a sense of the excitement attendees shared in being a part of this effort to break new ground by establishing a PH focus for results of current research. Until this meeting was held, physicians seeking such information had to look toward multiple meetings where research findings were presented, including large cardiology and pulmonology conferences, sporadic symposia, and a number of smaller conferences. Few, if any, of these meetings were dedicated to PH research per se. Because few physicians are able to attend all of these meetings pertaining to PH, the 2004 PHA Scientific Sessions were intended as the first of a series of conferences consolidating PH-related information and allowing professionals to network with others sharing a similar interest. The sessions also focused on another objective—presenting viewpoints of those working primarily in fields outside of PH, such as cancer and genetics. The coverage in this issue provides a representative sample of new directions in PH research from those who presented this information during the Scientific Sessions. A total of 47 abstracts were presented, 5 orally and the rest as posters. These abstracts covered the gamut of PH research, including clinical drug studies, patient demographics, hemodynamic monitoring, treatment strategies, and basic studies of the molecular processes and cell biology of PH. The Scientific Sessions proved to be a valuable addition to the well-established International PHA Conference. The financial support provided by the National Heart, Lung, and Blood Institute, the Centers for Disease Control and Prevention, the Office of Rare Diseases, and healthcare sponsors assured a forum for the productive exchange of information. Looking ahead, the next Scientific Sessions will be held in Minneapolis in 2006; you may want to make early note of a meeting that should not be missed. Michael McGoon, MD Guest Editor   Take it With You   Download this issue in PDF (2 MB)   Issue Sponsor Ads   Actelion (PDF) Accredo Therapeutics(PDF)   PHA Announcements   PH Doctor: A new professional section within PHA for physicians and MD/PhD-level researchers interested in pulmonary hypertension (PDF) (HTML) New PH Practice Guidelines from the ACCP (PDF) (HTML) November is PH Awareness Month / 2005 Postdoctoral Fellowship Awards Application Process (PDF)	Articles   Advances in Pulmonary Hypertension, Autumn 2004, Vol. 3, No. 3 cover close-up Click titles to read stories... Profiles in Pulmonary Hypertension: Robyn J. Barst, MD: Juggling Roles of Patient Advocate and Director of a Leading Research Center, Robyn Barst Meets the Challenge Great clinicians often distinguish themselves by fulfilling several demanding roles at the same time, by not only establishing their reputation as preeminent caregivers but also leading their colleagues toward excellence in other ways—for instance, in patient advocacy and establishment of referral centers. A case in point is Robyn J. Barst, MD. ... Exploring the Role of BMPR2 as Key Genetic Marker in Pulmonary Vascular Disease The genetics of pulmonary arterial hypertension is a rapidly growing investigative area that has witnessed significant advances in the past few years. A heritable form of pulmonary hypertension, familial primary pulmonary hypertension, was first recognized in 1948. In the general population the incidence of primary pulmonary hypertension ranges from 1 to 2 cases per million, and its pattern of inheritance is autosomal dominant with incomplete penetrance.... Why Potassium Channel Dysfunction May Be ‘Missing Link’ in Pathophysiology of PAH Potassium (K+) channel dysregulation in pulmonary artery smooth muscle cells (PASMCs) is important in understanding the etiology of pulmonary arterial hypertension (PAH), which is characterized by abnormalities in the vascular biology of the pulmonary circulation at all levels from lumen to adventitia.... Medical Treatment Options/Advances in Portopulmonary Hypertension: How the Spectrum Is Expanding Part 2 from previous issue's coverage: Portopulmonary hypertension is defined as the presence of an elevated pulmonary artery pressure (PAP; resting mean PAP >25 mm Hg or exercise PAP >30 mm Hg), with a normal pulmonary capillary wedge pressure in the presence of portal hypertension.... Pulmonary Hypertension Roundtable Recapping Highlights from Pulmonary Hypertension Association Scientific Sessions and Identifying Key Issues Driving Translational Research Featuring: Michael McGoon, MD Professor of Medicine and Consultant in the Division of Cardiovascular Diseases and Internal Medicine Mayo Clinic College of Medicine Rochester, Minnesota Victor F. Tapson, MD Professor of Medicine Division of Pulmonary and Critical Care Medicine Duke University Medical Center Durham, North Carolina Richard N. Channick, MD Associate Professor of Medicine Pulmonary and Critical Care Division University of California, San Diego Medical Center San Diego, California Vallerie V. McLaughlin, MD Associate Professor of Medicine Director, Pulmonary Hypertension Program University of Michigan Health System Ann Arbor, Michigan Ronald J. Oudiz, MD Associate Professor of Medicine UCLA School of Medicine Director, Liu Center for Pulmonary Hypertension, Division of Cardiology Harbor- UCLA Medical Center Torrance, California Ivan M. Robbins, MD Director, Pulmonary Hypertension Center Vanderbilt University Nashville, Tennessee
Notes   Editorial Advisory Board Editor-in-Chief Ronald J. Oudiz, MD Associate Professor of Medicine UCLA School of Medicine Director, Liu Center for Pulmonary Hypertension Division of Cardiology Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Torrance, California Immediate Past Editor Vallerie V. McLaughlin, MD Associate Professor of Medicine Director, Pulmonary Hypertension Program University of Michigan Health System Ann Arbor, Michigan Editor-in-Chief Elect Richard Channick, MD Professor of Clinical Medicine Pulmonary and Critical Care Division University of California, San Diego Medical Center San Diego, California Associate Editors Erika Berman Rosenzweig, MD Assistant Professor of Pediatrics Department of Pediatrics Columbia College of Physicians and Surgeons New York, New York Robert Frantz, MD Consultant in Cardiovascular Diseases and Internal Medicine Assistant Professor of Medicine Mayo Clinic College of Medicine Rochester, Minnesota Srinivas Murali, MD, FACC Professor of Medicine Drexel University College of Medicine Director, Division of Cardiovascular Medicine Medical Director, Gerald McGinnis Cardiovascular Institute Allegheny General Hospital Pittsburgh, Pennsylvania Publisher Pulmonary Hypertension Association Jack Stibbs, Board Chair Rino Aldrighetti, President Rachel Pokorney, Medical Services Associate Director Publishing Staff Stu Chapman, Executive Editor Susan Chapman, Managing Editor Heidi Green, Associate Editor Gloria Catalano, Production Director Michael McClain, Design Director PHA Office Pulmonary Hypertension Association 801 Roeder Road., St.e 400 Silver Spring, MD 20910 301-565-3004, 301-565-3994 (fax) www.PHAssociation.org Provided with an unrestricted educational grant from Actelion Pharmaceuticals, U.S., Inc. and Accredo Therapeuticss. © 2006 by Pulmonary Hypertension Association and DataMedica. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA. Editorial Offices Advances in Pulmonary Hypertension DataMedica 424 Dune Road Westhampton Beach, NY 11978 Tel: 631-288-7733 Fax: 631- 288-7744 Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association . The contents of the articles are independently determined ly the Editor and the Editorial Advisory Board. PHA's Scientific Leadership Council Editorial Mission Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association. Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.   Editorial Board Todd Bull, MD Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Denver, Colorado Murali Chakinala, MD Director, Pulmonary Hypertension Clinic Washington University School of Medicine St. Louis, Missouri Kristin Highland, MD Assistant Professor Division of Pulmonary and Critical Care Director, Pulmonary Hypertension Clinic Medical University of South Carolina Charleston, South Carolina Jim Maloney, MD Associate Professor of Pulmonary and Critical Care Medicine University of Colorado Health Sciences Center Denver, Colorado Ioana Preston, MD Assistant Professor of Medicine Tufts - New England Medical Center Boston, Massachusetts Zeenat Safdar, MD Assistant Professor of Medicine Department of Medicine, Pulmonary & Critical Care Section Pulmonary Hypertension Center Baylor College of Medicine Houston, Texas Rajan Saggar, MD Assistant Professor Division of Pulmonary and Critical Care Medicine and Hospitalists David Geffen School of Medicine UCLA Los Angeles, California Robert Schilz, DO, PhD Medical Director of Lung Transplantation and Pulmonary Vascular Disease University Hospital of Cleveland Case Western Reserve University Cleveland, Ohio Francisco Soto, MD, MS Assistant Professor Director, Pulmonary Hypertension Program Medical College of Wisconsin Milwaukee, Wisconsin Roxana Sulica, MD Assistant Professor of Medicine Albert Einstein College of Medicine Director, Beth Israel Pulmonary Hypertension Program Beth Israel Medical Center New York, New York

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