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Spring 2007, Vol. 6, No. 1

Editor’s Memo
 

A New Editor—Building on a Tradition of Excellence

Dr. Ronald OudizIt is with great pleasure that I assume the position of Editor-in-Chief of Advances in Pulmonary Hypertension. The journal is now in its 6th year of helping physicians by informing them of important trends in caring for patients with pulmonary hypertension. For the past 2 years, Vallerie V. McLaughlin, MD, as Editor-in-Chief in 2005 and 2006, has shown me how to orchestrate the journal into a state-of-the art reference for pulmonary hypertension that has become a stunning success, with a circulation that has grown to more than 36,000. From her timely topic selections to her meticulous, watchful eye, Dr McLaughlin has set the stage for the journal’s continued success and has provided us with healthy momentum to this end. An enormous credit goes to the journal’s founding editor, Victor F. Tapson, MD. Dr Tapson’s efforts in launching a journal with critical reviews of the newest areas of diagnosis and treatments for patients with pulmonary hypertension heralded a successful 3-year tenure, a tradition that continues today.

In this, the 21st issue of the journal, Roxana Sulica, MD, has taken the role of lead editor, overseeing three detailed reviews of the associations between hemoglobinopathies and pulmonary hypertension. The complex pathophysiology is evident in the review by Drs Gladwin and Kato. The clinical aspects of sicklecell- associated pulmonary hypertension are critically examined by Drs Machado and Castro, and a look into the clinical facets of thallasemia-associated pulmonary hypertension is provided by Drs Morris, Vichinsky, and Singer. These reviews remind us of the broad scope of conditions that contribute to a seemingly increasing prevalence of pulmonary vascular diseases that is being recognized throughout the world. Finally, an expert roundtable discusses the similarities and differences between pulmonary hypertension associated with hemoglobinopathies and pulmonary arterial hypertension in its classic definition, clearly calling attention to the need for therapeutic clinical trials.

I hope that you will enjoy this timely issue of Advances in Pulmonary Hypertension, the only journal of its kind, and share in the rewards of future issues.

Ronald J. Oudiz, MD
Editor-in-Chief

 

 
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Articles
 
Advances in Pulmonary Hypertension, Spring 2007, Vol. 6, No. 1

Click titles to read stories...

Profiles in Pulmonary Hypertension: Gérald Simonneau, MD: Pioneer, Mentor, and a Driving Force in Pulmonary Hypertension Research for His Colleagues (PDF)
When a physician’s curriculum vitae totals 232 articles that he has either authored or coauthored, there is little doubt that he ranks high in the pantheon of pulmonary hypertension researchers. This is just the beginning of Dr Gérald Simonneau’s credentials as a world-class physician and investigator, one of the most widely published authors in the fields of pulmonary hypertension, pulmonary vascular diseases, and pneumology.

Sickle Cell Disease-Associated Pulmonary Hypertension: Overview of Clinical Manifestations and Emerging Therapeutic Options (PDF)
Advances in the care of patients with sickle cell disease (SCD) and other hemolytic disorders have led to a significant improvement in their life expectancy. As this patient population ages, new chronic complications develop, and pulmonary hypertension (PH) is emerging as one of the leading causes of morbidity and mortality in adult patients with various hemolytic disorders.

Hemolysis-Associated Endothelial Dysfunction and Pulmonary Hypertension, an Emerging Cause of Death in the Hemoglobinopathies (PDF)
Medical advances in the management of patients with sickle cell disease (SCD), thalassemia, and other hemolytic anemias
have led to significant increases in life expectancy. Improved public health with neonatal genetic screening, parental and patient education, advances in red cell transfusion medicine safety, aggressive iron chelation therapy, penicillin prophylaxis for children under 6 years of age, immunization, and hydroxyurea therapy have all likely contributed to this effect on longevity. Now, as a generation of patients with SCD and thalassemia ages, new chronic vascular complications of these hemoglobinopathies develop.

Pulmonary Hypertension in Thalassemia: Association with Hemolysis, Arginine Metabolism Dysregulation, and a Hypercoagulable State (PDF)
The thalassemia syndromes are a heterogeneous group of inherited hemoglobin disorders resulting from impaired production of either the alpha or beta globin chain subunits of the hemoglobin tetramer. The clinical spectrum is a consequence of chronic hemolytic anemia and imbalanced globin chain accumulation.

Pulmonary Hypertension Roundtable: Sickle Cell Disease and Pulmonary Hypertension: Addressing the Mixed Pathology and Special Considerations in Diagnosis and Treatment (PDF)

 

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Notes
 

Editorial Advisory Board

Editor-in-Chief
Richard Channick, MD
Professor of Clinical Medicine
Pulmonary and Critical Care Division
University of California, San Diego Medical Center
San Diego, California

Immediate Past Editor
Ronald J. Oudiz, MD
Associate Professor of Medicine
The David Geffen School of Medicine at UCLA
Director, Liu Center for Pulmonary Hypertension
LA Biomedical Research Institute at Harbor-UCLA Medical Center

Editor-in-Chief Elect
Erika Berman Rosenzweig, MD
Director, Pulmonary Hypertension Center, Columbia University Medical Center Associate Professor of Clinical Pediatrics (in Medicine)

Associate Editors

Kristin Highland, MD
Assistant Professor of Medicine
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine
Medical University Of Carolina

Francisco Soto, MD, MS
Director, Pulmonary Hypertension Program
Pulmonary and Critical Care Medicine
Medical College of Wisconsin

Todd Bull, MD
Associate Professor of Medicine
Division of Pulmonary Sciences and Critical Care Medicine
University of Colorado Health Sciences Center

Robert Schilz, DO, PhD
Medical Director of Lung
Transplantation and Pulmonary Vascular Disease
University Hospital of Cleveland
Case Western Reserve University
Cleveland, Ohio


Publisher
Pulmonary Hypertension Association
Carl Hicks, Board Chair
Rino Aldrighetti, President
Sherrie Borden, Vice President, Medical and Patient Education

Publishing Staff
Managing Editor
Deborah L. McBride
McBride Strategic Services
mcbridedeb@aol.com
P: 773-348-5455
C: 312-307-5455
Design Director
Michael McClain

PHA Office
Pulmonary Hypertension Association
801 Roeder Road, Ste. 400
Silver Spring, MD 20910
301-565-3004, 301-565-3994 (fax)
www.PHAssociation.org

© 2009 by Pulmonary Hypertension Association. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA.

Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association. The contents of the articles are independently determined by the Editor and the Editorial Advisory Board.

PHA's Scientific Leadership Council

Editorial Mission
Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association.

Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.
 

Editorial Board

Charles Burger, MD
Medical Director, PH Clinic
Mayo Clinic
Jacksonville, FL

Karen Fagan, M.D.
Chief, Division of Pulmonary and Critical Care Medicine University of South Alabama

Eli Gabbay, MD
Lung Transplant Unit
Royal Perth Hospital

Nick Kim, M.D.
Associate Clinical Professor of Medicine
University of California San Diego

Deborah Jo Levine, M.D.
University of Texas Health Science Center at San Antonio
San Antonio, TX

Omar Minai, MD
Dept of Pulmonary, Allergy  and Critical Care Medicine

Myung Park, MD
Associate Professor of Medicine
Division of Pulmonary Sciences and Critical Care Medicine
University of Colorado Health Sciences Center

Fernando Torres, MD
Director Pulmonary Hypertension Clinic
UTSW Medical Center Dallas
University Hospital

Glenna Traiger, RN, MSN
Pulmonary & Critical Care
Pulmonary Hypertension CNS
University of California Los Angeles
Los Angeles, CA

R. James White, MD, PhD
Assistant Professor of Medicine, Pharmacology & Physiology
University of Rochester, Division of Pulmonary and CCM

Roham Zamanian, MD
Division of Pulmonary and Critical Care Medicine
Stanford University Medical Center

 

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