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Spring 2007, Vol. 6, No. 1

Editor’s Memo
 

A New Editor—Building on a Tradition of Excellence

Dr. Ronald OudizIt is with great pleasure that I assume the position of Editor-in-Chief of Advances in Pulmonary Hypertension. The journal is now in its 6th year of helping physicians by informing them of important trends in caring for patients with pulmonary hypertension. For the past 2 years, Vallerie V. McLaughlin, MD, as Editor-in-Chief in 2005 and 2006, has shown me how to orchestrate the journal into a state-of-the art reference for pulmonary hypertension that has become a stunning success, with a circulation that has grown to more than 36,000. From her timely topic selections to her meticulous, watchful eye, Dr McLaughlin has set the stage for the journal’s continued success and has provided us with healthy momentum to this end. An enormous credit goes to the journal’s founding editor, Victor F. Tapson, MD. Dr Tapson’s efforts in launching a journal with critical reviews of the newest areas of diagnosis and treatments for patients with pulmonary hypertension heralded a successful 3-year tenure, a tradition that continues today.

In this, the 21st issue of the journal, Roxana Sulica, MD, has taken the role of lead editor, overseeing three detailed reviews of the associations between hemoglobinopathies and pulmonary hypertension. The complex pathophysiology is evident in the review by Drs Gladwin and Kato. The clinical aspects of sicklecell- associated pulmonary hypertension are critically examined by Drs Machado and Castro, and a look into the clinical facets of thallasemia-associated pulmonary hypertension is provided by Drs Morris, Vichinsky, and Singer. These reviews remind us of the broad scope of conditions that contribute to a seemingly increasing prevalence of pulmonary vascular diseases that is being recognized throughout the world. Finally, an expert roundtable discusses the similarities and differences between pulmonary hypertension associated with hemoglobinopathies and pulmonary arterial hypertension in its classic definition, clearly calling attention to the need for therapeutic clinical trials.

I hope that you will enjoy this timely issue of Advances in Pulmonary Hypertension, the only journal of its kind, and share in the rewards of future issues.

Ronald J. Oudiz, MD
Editor-in-Chief

 

 
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Articles
 
Advances in Pulmonary Hypertension, Spring 2007, Vol. 6, No. 1

Click titles to read stories...

Profiles in Pulmonary Hypertension: Gérald Simonneau, MD: Pioneer, Mentor, and a Driving Force in Pulmonary Hypertension Research for His Colleagues (PDF)
When a physician’s curriculum vitae totals 232 articles that he has either authored or coauthored, there is little doubt that he ranks high in the pantheon of pulmonary hypertension researchers. This is just the beginning of Dr Gérald Simonneau’s credentials as a world-class physician and investigator, one of the most widely published authors in the fields of pulmonary hypertension, pulmonary vascular diseases, and pneumology.

Sickle Cell Disease-Associated Pulmonary Hypertension: Overview of Clinical Manifestations and Emerging Therapeutic Options (PDF)
Advances in the care of patients with sickle cell disease (SCD) and other hemolytic disorders have led to a significant improvement in their life expectancy. As this patient population ages, new chronic complications develop, and pulmonary hypertension (PH) is emerging as one of the leading causes of morbidity and mortality in adult patients with various hemolytic disorders.

Hemolysis-Associated Endothelial Dysfunction and Pulmonary Hypertension, an Emerging Cause of Death in the Hemoglobinopathies (PDF)
Medical advances in the management of patients with sickle cell disease (SCD), thalassemia, and other hemolytic anemias
have led to significant increases in life expectancy. Improved public health with neonatal genetic screening, parental and patient education, advances in red cell transfusion medicine safety, aggressive iron chelation therapy, penicillin prophylaxis for children under 6 years of age, immunization, and hydroxyurea therapy have all likely contributed to this effect on longevity. Now, as a generation of patients with SCD and thalassemia ages, new chronic vascular complications of these hemoglobinopathies develop.

Pulmonary Hypertension in Thalassemia: Association with Hemolysis, Arginine Metabolism Dysregulation, and a Hypercoagulable State (PDF)
The thalassemia syndromes are a heterogeneous group of inherited hemoglobin disorders resulting from impaired production of either the alpha or beta globin chain subunits of the hemoglobin tetramer. The clinical spectrum is a consequence of chronic hemolytic anemia and imbalanced globin chain accumulation.

Pulmonary Hypertension Roundtable: Sickle Cell Disease and Pulmonary Hypertension: Addressing the Mixed Pathology and Special Considerations in Diagnosis and Treatment (PDF)

 

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Notes
 

Editorial Advisory Board

Editor-in-Chief
Ronald J. Oudiz, MD
Associate Professor of Medicine
UCLA School of Medicine
Director, Liu Center for Pulmonary Hypertension
Division of Cardiology
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Torrance, California

Immediate Past Editor
Vallerie V. McLaughlin, MD
Associate Professor of Medicine
Director, Pulmonary Hypertension Program
University of Michigan Health System
Ann Arbor, Michigan

Editor-in-Chief Elect
Richard Channick, MD
Professor of Clinical Medicine
Pulmonary and Critical Care Division
University of California, San Diego Medical Center
San Diego, California

Associate Editors
Erika Berman Rosenzweig, MD
Assistant Professor of Pediatrics
Department of Pediatrics
Columbia College of Physicians and Surgeons
New York, New York

Robert Frantz, MD
Consultant in Cardiovascular
Diseases and Internal Medicine
Assistant Professor of Medicine
Mayo Clinic College of Medicine
Rochester, Minnesota

Srinivas Murali, MD, FACC
Professor of Medicine
Drexel University College of Medicine
Director, Division of Cardiovascular Medicine
Medical Director, Gerald McGinnis Cardiovascular Institute
Allegheny General Hospital
Pittsburgh, Pennsylvania

Publisher
Pulmonary Hypertension Association
Jack Stibbs, Board Chair
Rino Aldrighetti, President
Donica Merhazion, Medical Services Associate Director

Publishing Staff
Stu Chapman, Executive Editor
Susan Chapman, Managing Editor
Heidi Green, Associate Editor
Gloria Catalano, Production Director
Michael McClain, Design Director

PHA Office
Pulmonary Hypertension Association
801 Roeder Road., St.e 400
Silver Spring, MD 20910
301-565-3004, 301-565-3994 (fax)
www.PHAssociation.org

Provided with an unrestricted educational grant from Actelion Pharmaceuticals, U.S., Inc. and Accredo Therapeuticss.

© 2006 by Pulmonary Hypertension Association and DataMedica. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA.

Editorial Offices
Advances in Pulmonary Hypertension
DataMedica
424 Dune Road
Westhampton Beach, NY 11978
Tel: 631-288-7733
Fax: 631- 288-7744

Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association . The contents of the articles are independently determined ly the Editor and the Editorial Advisory Board.

PHA's Scientific Leadership Council

Editorial Mission
Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association.

Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.
 

Editorial Board

Todd Bull, MD
Division of Pulmonary Sciences and Critical Care Medicine
University of Colorado Health Sciences Center
Denver, Colorado

Murali Chakinala, MD
Director, Pulmonary Hypertension Clinic
Washington University School of Medicine
St. Louis, Missouri

Kristin Highland, MD
Assistant Professor
Division of Pulmonary and Critical Care
Director, Pulmonary Hypertension Clinic
Medical University of South Carolina
Charleston, South Carolina

Jim Maloney, MD
Associate Professor of Pulmonary and Critical Care Medicine
University of Colorado Health Sciences Center
Denver, Colorado

Ioana Preston, MD
Assistant Professor of Medicine
Tufts - New England Medical Center
Boston, Massachusetts

Zeenat Safdar, MD
Assistant Professor of Medicine
Department of Medicine, Pulmonary & Critical Care Section
Pulmonary Hypertension Center
Baylor College of Medicine
Houston, Texas

Rajan Saggar, MD
Assistant Professor
Division of Pulmonary and Critical Care
Medicine and Hospitalists
David Geffen School of Medicine
UCLA
Los Angeles, California

Robert Schilz, DO, PhD
Medical Director of Lung
Transplantation and Pulmonary Vascular Disease
University Hospital of Cleveland
Case Western Reserve University
Cleveland, Ohio

Francisco Soto, MD, MS
Assistant Professor
Director, Pulmonary Hypertension Program
Medical College of Wisconsin
Milwaukee, Wisconsin

Roxana Sulica, MD
Assistant Professor of Medicine
Albert Einstein College of Medicine
Director, Beth Israel Pulmonary Hypertension Program
Beth Israel Medical Center
New York, New York

 

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