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Spring 2005, Vol. 4, No. 1

Editor’s Memo
 

Passing the Torch: New Editorial Team Offers Broadest Spectrum of Expert Medical Opinion in Pulmonary Hypertension

This issue of Advances in Pulmonary Hypertension renews our commitment to the pulmonary hypertension community to provide valuable, timely, peer-reviewed scientific information relevant to clinical practice. Beginning with its first issue more than 3 years ago, the journal has embodied a team effort. Reflecting the fact that pulmonary hypertension is a complex disease, our editorial focus has been derived from experts whose areas of concentration reflect the diverse nature of this disorder and its complications.

As I assume the role of Editor-in-Chief, I pursue the same strategy because it has served us well. We will continue to build on a team effort of national and international experts whose goal is to find a cure for pulmonary hypertension. While the cure remains elusive, we are finding significant ways to improve the quality of life of patients with the disease; the journal serves as a chronicle of that story as it focuses on important developments in translational research and relates them to clinical considerations and decisions.

We are challenged by and appreciative of the leadership provided during the first 3 years of publication. We gratefully acknowledge the hard work and guidance provided by Victor F. Tapson, MD, Editor-in-Chief during this time. His contribution to the launch of the journal has left us with a solid foundation on which to build. His high editorial standards give us a legacy to live up to and the enthusiastic response to the journal from 30,000 readers makes us proud of Vic’s contribution. We are also grateful for the guidance provided by the Editorial Advisory Board of Richard N. Channick, MD, Sean Gaine, MD, PhD, Ronald J. Oudiz, MD, and Ivan M. Robbins, MD. The help from these leading academicians in identifying appropriate topics, participating in roundtable discussions and ensuring the overall quality of content inspires us to continue their excellent work.

With this issue, you will see more evidence of our team approach to pulmonary hypertension. Drs Channick and Oudiz will remain as Associate Editors, and we have added Ramona Doyle, MD, Karen Fagan, MD, and Oliver Sitbon, MD. Our Editorial Advisory Board has been expanded because more physicians have expressed a special interest in the journal and we look forward to working with them throughout the year as they participate in the editorial process. These physicians include: Gregory Ahearn, MD, Jacques Benisty, MD, Raymond Benza, MD, Erika Berman-Rosenzweig, MD, Todd Bull, MD, Murali Chakinala, MD, Jeffrey Edelman, MD, Jim Maloney, MD, Robert Schiltz, DO, and Roxana Sulica, MD. (read more...)

Vallerie V. McLaughlin, MD
Editor-in-Chief

 

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Articles
 
Advances in Pulmonary Hypertension, Spring 2005, Vol. 4, No. 1

Click titles to read stories...

Profiles in Pulmonary Hypertension:
Jim Loyd, MD: Probing Early Mysterious Deaths in Families, Jim Loyd, MD, Helps Solve Riddle of Genetic Mutation in PPH Soon after a 30-year-old woman with primary pulmonary hypertension (PPH) was referred to Jim Loyd, MD, the first pieces of a huge and complex puzzle began falling into place....

Defining the Role and Clinical Relevance of BMPR2 Mutations In Pulmonary Arterial Hypertension: Recent advances in molecular genetics during the past four years have defined two genes that causally underlie the development of pulmonary arterial hypertension.

TGF-beta Receptors in Pulmonary Arterial Hypertension: The HHT Connection: Substantial progress in delineating the molecular and genetic basis of pulmonary arterial hypertension has placed the TGFbeta cell-signaling pathway as the centerpiece of contemporary thinking about the pathogenesis of this disorder.

The Serotonin Pathway in Pulmonary Hypertension: The effects of serotonin (5-hydroxytryptamine, 5-HT) on the pulmonary circulation have been investigated because of the reported increased risk of idiopathic pulmonary arterial hypertension (IPH) in patients who used appetite suppressants that interact with 5-HT.

Potential Genetic Contributions to Nonidiopathic, Nonfamilial Pulmonary Hypertension: The recent Venice Classification of pulmonary hypertension1 includes diseases that are definitely or possibly genetic and associated with the development of pulmonary hypertension.

The Future of Genetics in Pulmonary Arterial Hypertension: Research into the genetic basis of pulmonary arterial hypertension is going forward with increasing intensity. It appears that mutations in bone morphogenetic protein receptor type II (BMPR2) and activin receptor-like kinase-1 (ALK1) genes will be the most common genetic risk factors for the development of pulmonary arterial hypertension.

 

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Notes
 

Editorial Advisory Board

Editor-in-Chief
Ronald J. Oudiz, MD
Associate Professor of Medicine
UCLA School of Medicine
Director, Liu Center for Pulmonary Hypertension
Division of Cardiology
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Torrance, California

Immediate Past Editor
Vallerie V. McLaughlin, MD
Associate Professor of Medicine
Director, Pulmonary Hypertension Program
University of Michigan Health System
Ann Arbor, Michigan

Editor-in-Chief Elect
Richard Channick, MD
Professor of Clinical Medicine
Pulmonary and Critical Care Division
University of California, San Diego Medical Center
San Diego, California

Associate Editors
Erika Berman Rosenzweig, MD
Assistant Professor of Pediatrics
Department of Pediatrics
Columbia College of Physicians and Surgeons
New York, New York

Robert Frantz, MD
Consultant in Cardiovascular
Diseases and Internal Medicine
Assistant Professor of Medicine
Mayo Clinic College of Medicine
Rochester, Minnesota

Srinivas Murali, MD, FACC
Professor of Medicine
Drexel University College of Medicine
Director, Division of Cardiovascular Medicine
Medical Director, Gerald McGinnis Cardiovascular Institute
Allegheny General Hospital
Pittsburgh, Pennsylvania

Publisher
Pulmonary Hypertension Association
Jack Stibbs, Board Chair
Rino Aldrighetti, President
Rachel Pokorney, Medical Services Associate Director

Publishing Staff
Stu Chapman, Executive Editor
Susan Chapman, Managing Editor
Heidi Green, Associate Editor
Gloria Catalano, Production Director
Michael McClain, Design Director

PHA Office
Pulmonary Hypertension Association
801 Roeder Road., St.e 400
Silver Spring, MD 20910
301-565-3004, 301-565-3994 (fax)
www.PHAssociation.org

Provided with an unrestricted educational grant from Actelion Pharmaceuticals, U.S., Inc. and Accredo Therapeuticss.

© 2006 by Pulmonary Hypertension Association and DataMedica. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA.

Editorial Offices
Advances in Pulmonary Hypertension
DataMedica
424 Dune Road
Westhampton Beach, NY 11978
Tel: 631-288-7733
Fax: 631- 288-7744

Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association . The contents of the articles are independently determined ly the Editor and the Editorial Advisory Board.

PHA's Scientific Leadership Council

Editorial Mission
Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association.

Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.
 

Editorial Board

Todd Bull, MD
Division of Pulmonary Sciences and Critical Care Medicine
University of Colorado Health Sciences Center
Denver, Colorado

Murali Chakinala, MD
Director, Pulmonary Hypertension Clinic
Washington University School of Medicine
St. Louis, Missouri

Kristin Highland, MD
Assistant Professor
Division of Pulmonary and Critical Care
Director, Pulmonary Hypertension Clinic
Medical University of South Carolina
Charleston, South Carolina

Jim Maloney, MD
Associate Professor of Pulmonary and Critical Care Medicine
University of Colorado Health Sciences Center
Denver, Colorado

Ioana Preston, MD
Assistant Professor of Medicine
Tufts - New England Medical Center
Boston, Massachusetts

Zeenat Safdar, MD
Assistant Professor of Medicine
Department of Medicine, Pulmonary & Critical Care Section
Pulmonary Hypertension Center
Baylor College of Medicine
Houston, Texas

Rajan Saggar, MD
Assistant Professor
Division of Pulmonary and Critical Care
Medicine and Hospitalists
David Geffen School of Medicine
UCLA
Los Angeles, California

Robert Schilz, DO, PhD
Medical Director of Lung
Transplantation and Pulmonary Vascular Disease
University Hospital of Cleveland
Case Western Reserve University
Cleveland, Ohio

Francisco Soto, MD, MS
Assistant Professor
Director, Pulmonary Hypertension Program
Medical College of Wisconsin
Milwaukee, Wisconsin

Roxana Sulica, MD
Assistant Professor of Medicine
Albert Einstein College of Medicine
Director, Beth Israel Pulmonary Hypertension Program
Beth Israel Medical Center
New York, New York

 

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