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Spring 2006, Vol. 5, No. 1

Editor’s Memo   Chronicling the Evolution of a Journal: We Welcome New Support to Meet Growing Educational Needs of Physicians “Ten years ago physicians treating pulmonary hypertension would have been amazed at today’s options for managing a disease that had a dismal prognosis. Progress has been swift, and we stand at the threshold of a new era in treatment. As our treatment options for pulmonary hypertension have expanded dramatically, so has our need for more information to keep pace with major advances.” With this statement, our previous Editor-in-Chief, Victor Tapson, MD, kicked off the first issue of Advances in Pulmonary Hypertensionin Spring 2002. With this hefty, 48-page issue, we stand somewhat similarly on the threshold of a new era—this one in providing essential information to our readers with a journal that continues to evolve as the most comprehensive source of knowledge for clinicians whose primary focus is pulmonary hypertension. We are pleased to welcome a new cohort of commercial supporters to Advances in Pulmonary Hypertension because it means the journal can (1) expand its coverage by bringing readers more content on the most important topics relevant to the care of patients, (2) present more information on translational research by investigators worldwide, and (3) help us to more firmly establish the journal as an authoritative source as we eventually pursue a designation as an indexed journal on the MEDLINE database. The support by additional sponsors suggests exactly how far we are moving into the new era of treatment and the therapies represented here reflect the growing commitment by the pharmaceutical industry to research and development of drugs that expand the spectrum of therapy. While it is encouraging to see this support, we remain committed to a journal that will present rigorously peer-reviewed, unbiased, scientifically valid and balanced information, reflecting the highest standards of care by the medical community. This community is well represented on our Editorial Advisory Board, our Editorial Committee and the Scientific Leadership Council of the Pulmonary Hypertension Association. All of the physicians listed on page 3 play an integral role in planning the program of the Pulmonary Hypertension Association (PHA), including the Scientific Sessions held every other year. Please see pages 24 and 25 for information on this year’s dynamic International Conference in Minneapolis, Roadmap to a Cure, June 23 to 25. Many of these physicians also take on leadership roles in developing content for our conferences and guiding creation of manuscripts for our journal. Our Associate Editor for this issue, Ronald J. Oudiz, MD, had the particularly daunting task of overseeing the content development of this expanded issue and we greatly appreciate his contribution in reviewing and editing the manuscripts. As Dr Oudiz points out in his introduction, this issue focuses on the very common but poorly understood problem of pulmonary hypertension due to left heart disease, including reviews examining the relationship between diastolic heart failure and pulmonary hypertension, another review on pulmonary hypertension out of proportion to left heart disease, and heart failure patients with pulmonary hypertension referred for cardiac transplantation. In looking ahead, I recall another perspective from the first Editor’s Memo by Dr Tapson who also noted, “As exciting as the last decade has been in expanding the spectrum of therapy, the years ahead look even more promising as we gather more data on the use of endothelin receptor antagonists and perhaps additional agents that will address the proliferative mechanisms of the disease.” We look forward to continuing our mission to put these trends in intelligent perspective and welcome your comments and suggestions. Vallerie V. McLaughlin, MD Editor-in-Chief	Articles   Advances in Pulmonary Hypertension, Spring 2006, Vol. 5, No. 1 cover close-up Click titles to read stories... Profiles in Pulmonary Hypertension: Jack Reeves, MD, Remembered as ‘Renaissance Ideal,” in Stellar Career Spanning Diverse Pulmonary Research It is rare for a clinician to be described as someone who came “as close as any of us will see to the Renaissance ideal.” Yet this is the praise earned by John “Jack” Reeves, MD, who died last September in a motor vehicle-bicycle accident in Colorado where he earned a reputation as a preeminent clinician and scholar... Diagnostic Dilemmas: Diastolic Heart Failure Causing Pulmonary Hypertension and Pulmonary Hypertension Causing Diastolic Dysfunction: As reviewed [in this article], the pathophysiologic mechanisms present in patients with diastolic heart failure may be heterogeneous. Although pulmonary hypertension has been reported in patients with diastolic heart failure, its prevalence and severity remain poorly defined.... Pulmonary Hypertension Out of Proportion to Left Heart Disease: Classically, the term pulmonary hypertension (PH) refers to a resting mean pulmonary pressure greater than 25 mmHg. There are many different etiologies of PH, but by and large, the most common cause is pulmonary venous hypertension (PVH).... Pulmonary Hypertension in Heart Failure Patients Who Are Referred for Cardiac Transplantation: Left-sided heart failure is an important and common cause of pulmonary hypertension (PH). In the United States, >5 million people are affected by heart failure, and approximately 550,000 new cases are diagnosed annually... Pulmonary Hypertension Roundtable Controversies and Consensus in PH With Left Heart Disease: Dosing Issues, Transplant Considerations, Wedge Pressure Targets, Postop Drug Selection, and More   PHA Announcements   7th International PH Conference (PDF) (HTML) Diagnostic CD (PDF) (HTML) K08/K23 Program Announcement (PDF) (HTML)     Take it With You   Download this issue in PDF (4.2 MB)     Issue Sponsor Ads   Actelion (PDF) GlaxoSmithKline (PDF) Pfizer (PDF) United Therapeutics (PDF) CoTherix (PDF) Encysive (PDF)
Notes   Editorial Advisory Board Editor-in-Chief Ronald J. Oudiz, MD Associate Professor of Medicine UCLA School of Medicine Director, Liu Center for Pulmonary Hypertension Division of Cardiology Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Torrance, California Immediate Past Editor Vallerie V. McLaughlin, MD Associate Professor of Medicine Director, Pulmonary Hypertension Program University of Michigan Health System Ann Arbor, Michigan Editor-in-Chief Elect Richard Channick, MD Professor of Clinical Medicine Pulmonary and Critical Care Division University of California, San Diego Medical Center San Diego, California Associate Editors Erika Berman Rosenzweig, MD Assistant Professor of Pediatrics Department of Pediatrics Columbia College of Physicians and Surgeons New York, New York Robert Frantz, MD Consultant in Cardiovascular Diseases and Internal Medicine Assistant Professor of Medicine Mayo Clinic College of Medicine Rochester, Minnesota Srinivas Murali, MD, FACC Professor of Medicine Drexel University College of Medicine Director, Division of Cardiovascular Medicine Medical Director, Gerald McGinnis Cardiovascular Institute Allegheny General Hospital Pittsburgh, Pennsylvania Publisher Pulmonary Hypertension Association Jack Stibbs, Board Chair Rino Aldrighetti, President Rachel Pokorney, Medical Services Associate Director Publishing Staff Stu Chapman, Executive Editor Susan Chapman, Managing Editor Heidi Green, Associate Editor Gloria Catalano, Production Director Michael McClain, Design Director PHA Office Pulmonary Hypertension Association 801 Roeder Road., St.e 400 Silver Spring, MD 20910 301-565-3004, 301-565-3994 (fax) www.PHAssociation.org Provided with an unrestricted educational grant from Actelion Pharmaceuticals, U.S., Inc. and Accredo Therapeuticss. © 2006 by Pulmonary Hypertension Association and DataMedica. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA. Editorial Offices Advances in Pulmonary Hypertension DataMedica 424 Dune Road Westhampton Beach, NY 11978 Tel: 631-288-7733 Fax: 631- 288-7744 Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association . The contents of the articles are independently determined ly the Editor and the Editorial Advisory Board. PHA's Scientific Leadership Council Editorial Mission Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association. Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.   Editorial Board Todd Bull, MD Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center Denver, Colorado Murali Chakinala, MD Director, Pulmonary Hypertension Clinic Washington University School of Medicine St. Louis, Missouri Kristin Highland, MD Assistant Professor Division of Pulmonary and Critical Care Director, Pulmonary Hypertension Clinic Medical University of South Carolina Charleston, South Carolina Jim Maloney, MD Associate Professor of Pulmonary and Critical Care Medicine University of Colorado Health Sciences Center Denver, Colorado Ioana Preston, MD Assistant Professor of Medicine Tufts - New England Medical Center Boston, Massachusetts Zeenat Safdar, MD Assistant Professor of Medicine Department of Medicine, Pulmonary & Critical Care Section Pulmonary Hypertension Center Baylor College of Medicine Houston, Texas Rajan Saggar, MD Assistant Professor Division of Pulmonary and Critical Care Medicine and Hospitalists David Geffen School of Medicine UCLA Los Angeles, California Robert Schilz, DO, PhD Medical Director of Lung Transplantation and Pulmonary Vascular Disease University Hospital of Cleveland Case Western Reserve University Cleveland, Ohio Francisco Soto, MD, MS Assistant Professor Director, Pulmonary Hypertension Program Medical College of Wisconsin Milwaukee, Wisconsin Roxana Sulica, MD Assistant Professor of Medicine Albert Einstein College of Medicine Director, Beth Israel Pulmonary Hypertension Program Beth Israel Medical Center New York, New York

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