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Summer 2005, Vol. 4, No. 2

Editor’s Memo
 

ATS Meeting Serves as Useful Measure
Of Rising Interest in Pulmonary Hypertension

This year’s meeting of the American Thoracic Society (ATS) was exciting from several vantage points, including the fact that it was the 100th anniversary of the ATS, a striking achievement for this venerable organization. The ATS meeting is the largest gathering of pulmonary and critical care specialists in the world. For those of us
involved with or closely following developments in pulmonary hypertension
(PH), the meeting was also notable because of the extensive focus devoted to PH at this meeting, in scientific sessions, debates,
abstracts, and original research. As a moderator for some of these sessions, I was fortunate enough to personally become part of the lively and challenging discussions, including the controversies that fueled the debates.

Evidence of the growing interest in PH at this meeting can be quantified if one likes to keep track statistically of such trends. The ATS web site, for example, lists 322 abstracts on PH alone. This number is a good barometer for the rising interest in PH, especially when one considers that in 2004 the ATS had 272 abstracts on PH featured in its program. One of the abstracts in the 2005 session concerning the relationship of hypoxemia to pulmonary artery pressure in pulmonary arterial hypertension (PAH) was presented by Duke University investigators, including Victor F. Tapson, MD, my predecessor as Editor-in-Chief of Advances in Pulmonary Hypertension,
and his colleague, Richard C. Redman, MD.

Although PH associated with hypoxemic lung disease is a common problem, it is
one of those areas where we need more information to more precisely identify how it should be classified. As their abstract and poster pointed out, little data exist regarding hypoxemia in patients with PAH. While it might appear intuitive, a clear correlation between hypoxemia and pulmonary artery pressure in this disease has not been
shown, yet further characterization of this relationship may provide insight into the pathophysiology and clinical manifestations of PAH. As the conclusion notes:
patients with severe PAH were significantly more hypoxemic than patients with mild to moderate PAH. Drs Tapson and Redman conclude that hypoxemia is generally more pronounced as PAH becomes more severe and may be more important in the pathophysiology of PAH than previously appreciated.

For more insights on this relationship, I encourage readers to review the information in an article by Robert Schilz, DO, PhD, in this issue, as well as the Roundtable discussion chaired by Richard Channick, MD. We would like to express our appreciation to Dr Channick for serving as the Guest Editor of this issue and bringing together the editorial content focusing on PH associated with lung diseases.

Vallerie V. McLaughlin, MD
Editor-in-Chief

 
Articles
 
Advances in Pulmonary Hypertension, Summer 2005, Vol. 4, No. 2

Click titles to read stories...

Profiles in Pulmonary Hypertension:
John West, MD: Climbing With Dr John West in the Rarefied Air of Pulmonary Research: From Mount Everest to the University of California, San Diego
When you have been recruited as a clinical investigator to climb Mount Everest with Sir Edmund Hillary, have coauthored 427 articles and 21 books,... what worlds are left to conquer? Quite a few, says John West, MD...

Pulmonary Hypertension Due to Respiratory Disease: Pathogenesis and Diagnostic Approach: Since the discovery of hypoxic pulmonary vasoconstriction six decades ago, respiratory physiologists and clinicians have been fascinated by pulmonary hypertension in the setting of chronic lung disease.

The New UNOS Lung Transplantation Allocation System: Lung or heart-lung transplantation is an acceptable therapeutic option for patients with advanced lung diseases, including patients with pulmonary hypertension in whom all other therapies have been exhausted. However, the supply of donor lungs is scarce relative to the demand.

Treatment of Pulmonary Hypertension Related to Disorders of Hypoxia: As part of an ongoing series of articles on the evaluation and management of pulmonary hypertension, this article will address issues in the treatment of pulmonary hypertension related to hypoxemia.

Pulmonary Hypertension Roundtable

Pulmonary Hypertension in Lung/Respiratory Disease: How Important? What to Do?

 

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Notes
 

Editorial Advisory Board

Editor-in-Chief
Ronald J. Oudiz, MD
Associate Professor of Medicine
UCLA School of Medicine
Director, Liu Center for Pulmonary Hypertension
Division of Cardiology
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Torrance, California

Immediate Past Editor
Vallerie V. McLaughlin, MD
Associate Professor of Medicine
Director, Pulmonary Hypertension Program
University of Michigan Health System
Ann Arbor, Michigan

Editor-in-Chief Elect
Richard Channick, MD
Professor of Clinical Medicine
Pulmonary and Critical Care Division
University of California, San Diego Medical Center
San Diego, California

Associate Editors
Erika Berman Rosenzweig, MD
Assistant Professor of Pediatrics
Department of Pediatrics
Columbia College of Physicians and Surgeons
New York, New York

Robert Frantz, MD
Consultant in Cardiovascular
Diseases and Internal Medicine
Assistant Professor of Medicine
Mayo Clinic College of Medicine
Rochester, Minnesota

Srinivas Murali, MD, FACC
Professor of Medicine
Drexel University College of Medicine
Director, Division of Cardiovascular Medicine
Medical Director, Gerald McGinnis Cardiovascular Institute
Allegheny General Hospital
Pittsburgh, Pennsylvania

Publisher
Pulmonary Hypertension Association
Jack Stibbs, Board Chair
Rino Aldrighetti, President
Rachel Pokorney, Medical Services Associate Director

Publishing Staff
Stu Chapman, Executive Editor
Susan Chapman, Managing Editor
Heidi Green, Associate Editor
Gloria Catalano, Production Director
Michael McClain, Design Director

PHA Office
Pulmonary Hypertension Association
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Silver Spring, MD 20910
301-565-3004, 301-565-3994 (fax)
www.PHAssociation.org

Provided with an unrestricted educational grant from Actelion Pharmaceuticals, U.S., Inc. and Accredo Therapeuticss.

© 2006 by Pulmonary Hypertension Association and DataMedica. All rights reserved. None of the contents may be reproduced in any form whatsoever without the written permission of PHA.

Editorial Offices
Advances in Pulmonary Hypertension
DataMedica
424 Dune Road
Westhampton Beach, NY 11978
Tel: 631-288-7733
Fax: 631- 288-7744

Advances in Pulmonary Hypertension is circulated to cardiologists, pulmonologists, rheumatologists and other selected physicians by the Pulmonary Hypertension Association . The contents of the articles are independently determined ly the Editor and the Editorial Advisory Board.

PHA's Scientific Leadership Council

Editorial Mission
Advances in Pulmonary Hypertension is committed to help physicians in their clinical decision making by informing them of important trends affecting their practice. Analyzing the impact of new findings and covering current information in the peer-reviewed literature, Advances in Pulmonary Hypertension is published four times a year. Advances in Pulmonary Hypertension is the official journal of the Pulmonary Hypertension Association.

Each article in this journal has been reviewed and approved by members of the Editorial Advisory Board.
 

Editorial Board

Todd Bull, MD
Division of Pulmonary Sciences and Critical Care Medicine
University of Colorado Health Sciences Center
Denver, Colorado

Murali Chakinala, MD
Director, Pulmonary Hypertension Clinic
Washington University School of Medicine
St. Louis, Missouri

Kristin Highland, MD
Assistant Professor
Division of Pulmonary and Critical Care
Director, Pulmonary Hypertension Clinic
Medical University of South Carolina
Charleston, South Carolina

Jim Maloney, MD
Associate Professor of Pulmonary and Critical Care Medicine
University of Colorado Health Sciences Center
Denver, Colorado

Ioana Preston, MD
Assistant Professor of Medicine
Tufts - New England Medical Center
Boston, Massachusetts

Zeenat Safdar, MD
Assistant Professor of Medicine
Department of Medicine, Pulmonary & Critical Care Section
Pulmonary Hypertension Center
Baylor College of Medicine
Houston, Texas

Rajan Saggar, MD
Assistant Professor
Division of Pulmonary and Critical Care
Medicine and Hospitalists
David Geffen School of Medicine
UCLA
Los Angeles, California

Robert Schilz, DO, PhD
Medical Director of Lung
Transplantation and Pulmonary Vascular Disease
University Hospital of Cleveland
Case Western Reserve University
Cleveland, Ohio

Francisco Soto, MD, MS
Assistant Professor
Director, Pulmonary Hypertension Program
Medical College of Wisconsin
Milwaukee, Wisconsin

Roxana Sulica, MD
Assistant Professor of Medicine
Albert Einstein College of Medicine
Director, Beth Israel Pulmonary Hypertension Program
Beth Israel Medical Center
New York, New York

 

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