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PHA News Archive - September 10, 2004

vol 5, Number 19

PHA News September 10, 2004
PHA News is an e-mail newsletter from the Pulmonary Hypertension Association covering PH related topics.

PHA News editor - Sally Maddox skmaddox@bellsouth.net
reaching over 4800 subscribers

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Survival Guide

Pulmonary Hypertension -
A Patient's Survival Guide

The premiere information resource for people living and dealing with PH

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Topics For This Issue
7-year-old overcomes rare condition
CoTherix, Inc. Announces Priority Review Designation by the FDA for Ventavis NDA
Thelin(TM) May Offer Alternative for PAH Patients Who Have Failed on Bosentan, According to Data Presented at European Respiratory Society Congress

Viagra Looms as Rival for Actelion, Data Due Oct

Safety and Hemodynamic Effects of Pulmonary Angiography in Patients with Pulmonary Hypertension: 10-Year Single-Center Experience

7-year-old overcomes rare condition

Local child fights primary pulmonary hypertension

MADISON TOWNSHIP -- He has his father's lanky frame, his mother's large hazel eyes and the sweet cheerfulness of a happy 7-year-old. No one knows where Jared Fracker, of Madison Township, got his rare, usually disabling or fatal disease.

It has a dauntingly cumbersome name, primary pulmonary hypertension, a progressive disease of unknown cause that results in the narrowing of the blood vessels in the lungs, causing high blood pressure and eventually leading to heart failure, according to the American Lung Association.

Read more...
(http://www.newarkadvocate.com/news/
stories/20040907/localnews/1193312.html)

CoTherix, Inc. Announces Priority Review Designation by the FDA for Ventavis NDA
SOUTH SAN FRANCISCO, Calif., Sept. 8 /PRNewswire/ -- CoTherix, Inc. today announced that its New Drug Application (NDA) for Ventavis(R) (iloprost) Inhalation Solution has been accepted for review by the U.S. Food and Drug Administration and has been granted priority review designation. The priority review designation establishes a target action date of December 31, 2004, for the Ventavis NDA. Additionally, CoTherix's request for orphan drug designation has been granted for the use of Ventavis to treat pulmonary arterial hypertension.

Read Article
(http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/09-08-2004/0002246331&EDATE=)

Thelin(TM) May Offer Alternative for PAH Patients Who Have Failed on Bosentan, According to Data Presented at European Respiratory Society Congress

HOUSTON, Sept. 8 /PRNewswire-FirstCall/ -- Encysive Pharmaceuticals
(Nasdaq: ENCY) today announced the presentation of new clinical data on
Thelin(TM) (sitaxsentan) in pulmonary arterial hypertension (PAH), at the European Respiratory Society (ERS) 14th Annual Congress (September 4-8, 2004) in Scotland. Data from this single center experience suggests that Thelin may offer an alternative for PAH patients whose conditions are worsening on bosentan. Two other abstracts were presented at the ERS meeting on Thelin.

Data from this first study was presented by clinical investigator Adaani Frost, M.D., Baylor College of Medicine, Houston, Texas. Entitled, "Sitaxsentan Sodium for the Treatment of Pulmonary Arterial Hypertension in Patients Failing Bosentan: Preliminary Single Center Data," the trial showed that 10 out of 11 PAH patients who had failed on bosentan due to clinical deterioration or liver toxicities improved or stabilized when given Thelin oral therapy. All 10 patients are continuing on Thelin today, some as long as 10 months.

Read Article
(http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/09-08-2004/0002245916&EDATE=)

Viagra Looms as Rival for Actelion, Data Due Oct
LONDON (Reuters) - Pfizer Inc will give results of a clinical trial next month that could confirm its best-selling anti-impotence drug Viagra as a competitor to Actelion's Tracleer in treating a deadly form of hypertension.
A Pfizer spokeswoman confirmed on Friday that results of a study looking at Viagra's use in treating pulmonary arterial hypertension would be presented at the annual meeting of the American College of Chest Physicians in Seattle on October 27.

Investors in Swiss biotech firm Actelion have been anxiously awaiting the data, which is widely expected to confirm that Viagra is an effective medicine in controlling the crippling heart and lung disease.

Read Article
(http://www.reuters.com/newsArticle.jhtml
?type=healthNews&storyID=6147466)

Safety and Hemodynamic Effects of Pulmonary Angiography in Patients with Pulmonary Hypertension: 10-Year Single-Center Experience

...retrospective review was performed for all patients who underwent pulmonary angiography over a 10-year period at a single institution. Patients with moderate pulmonary hypertension (pulmonary artery pressure, 30-59 mm Hg) and severe pulmonary hypertension (pulmonary artery pressure, 60 mm Hg) served as the study population. Demographic data, clinical indication, pre- and postcontrast pulmonary artery pressure measurements, type of pulmonary hypertension, contrast agent volume, complications, and American Society of Anesthesiologists (ASA) classification were recorded for all patients and compared.

Read Article
(http://www.ajronline.org/cgi/content/abstract/183/3/779)


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