PHA/NHLBI K08/K23 Award Winner 2009

Stephen Mathai, MD Stephen C. Mathai, MD, MHS

Division of Pulmonary and Critical Care
Johns Hopkins University School of Medicine
"Neurohormonal Activation in Scleroderma Related Pulmonary Hypertension"
Mentored Patient-Oriented Research Career Development Award (K23)
August 1, 2009 - July 31, 2014

Summary of Research Project:

"Neurohormonal Activation in Scleroderma Related Pulmonary Hypertension"

Survival in pulmonary arterial hypertension (PAH) related scleroderma is worse than in idiopathic PAH. The reasons for this survival difference are unclear but may be related to an exaggerated response to stress on the heart via the neurohormonal axis (NHA). Previous studies of patients with heart failure have shown that the response to stress on the heart through the NHA determines disease severity and survival and may be modified with specific medications. We believe similar mechanisms are involved in PAH related to scleroderma, may explain poor patient survival, and can potentially be modified by therapy. Our project focuses on defining the differences in NHA response to stress on the heart between these two forms of PAH and on identifying genetic factors that may predict the development of PAH, severity of disease and response to therapy.

The identification of factors that influence not only the severity of PAH but also the development of disease is of paramount importance to advance our understanding of the disease. Prior research has established the integral role of the NHA in heart failure; however, little is known about the NHA in PAH. Our study will examine the role of NHA in PAH to determine its relationship to disease severity and outcomes, and potentially define treatment pathways. Further, we hope to identify specific genetic risk factors for the development of PAH that could be applied in screening programs for at-risk patients, such as those with scleroderma.

Curriculum Vitae

Stephen C. Mathai, MD, MHS
Assistant Professor of Medicine, Johns Hopkins University School of Medicine

EDUCATION AND TRAINING

1990-1994 BA Rutgers College
New Brunswick, NJ
Major: Biology
1995-1999 MD Jefferson Medical College
Philadelphia, PA
1999-2000 Intern
Internal Medicine
Thomas Jefferson University Hospital
Philadelphia, PA
2000-2002 Resident
Internal Medicine
Thomas Jefferson University Hospital
Philadelphia, PA
2002-2003 Chief Medical Resident
Internal Medicine
Thomas Jefferson University Hospital
Philadelphia, PA
2003-2008 Fellow
Pulmonary and Critical Care Medicine
Johns Hopkins University School of Medicine
Baltimore, MD
2003-2005 MHS Johns Hopkins Bloomberg School of Public Health
Baltimore, MD

Professional Experience

Dates Position Institution
2002-2003 Instructor of Medicine Thomas Jefferson University Hospital
Philadelphia, PA
2003-2007 Intensivist Greater Baltimore Medical Center
Baltimore, MD
2008-2009 Instructor of Medicine Johns Hopkins University School of Medicine
Baltimore, MD
2009-present Assistant Professor Johns Hopkins University School of Medicine
Baltimore, MD

RESEARCH ACTIVITIES

Publications: Peer Reviewed Original Science Research

  1. Girgis RE, Mathai SC, Krishnan JA, Wigley FM, Hassoun PM. Long term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. J Heart Lung Transplant 2005; 24(10):1626-31.
  2. Fisher MR, Mathai SC, Champion HC, Girgis RE, Housten-Harris T, Hummers L, Krishnan JA, Wigley FM, Hassoun PM. Clinical differences between idiopathic and scleroderma related pulmonary hypertension. Arthritis Rheum. 2006 Aug 31;54(9):3043-3050.
  3. Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion HC, Girgis RE, and Hassoun PM. Tricuspid annular displacement predicts right ventricular function and survival in PAH.  Am J Respir Crit Care Med 2006; 174(9):1034-1041.
  4. Mathai SC, Girgis RE, Fisher MR, Champion HC, Housten-Harris T, Zaiman A, and Hassoun PM. Addition of sildenafil to bosentan therapy in the treatment of pulmonary arterial hypertension. Eur Respir J 2007; 29(3):469-475.
  5. Grigoryev DN, Mathai SC, Fisher MR, Girgis RE, Zaiman AL, Cheadle C, Hummers L, Garcia JGN, Barnes KC, Wigley FM, Hassoun PM. Identification of candidate genes in scleroderma-associated pulmonary arterial hypertension. Transl Res 2008; 151(4):197-207.
  6. Forfia PR, Mathai SC, Fisher MR, Housten-Harris T, Hemnes AR, Champion HC, Girgis RE, Hassoun PM.  Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med 2008; 177(12):1364-9.
  7. Krishnan V, McCormack MC, Mathai SC, Agarwal S, Richardson B, Horton MR, Polito AJ, Collop NA, Danoff SK. Sleep quality and health-related quality of life in idiopathic pulmonary fibrosis.  Chest 2008; 134:693-8.
  8. Tedford RJ,  Hemnes AR, Russell SD, Wittstein IS, Mahmud M, Zaiman A, Mathai SC, Thiemann D,  Hassoun PM, Girgis RE, Orens JB, Yuh D, Conte JV, and Champion HC. PDE5A inhibitor sildenafil reverses fixed elevated PVR in end stage left sided heart failure allowing for potential cardiac transplantation. Circ Heart Fail 2008; 1:213-9.
  9. Mathai SC, Housten-Harris T, Hummers LK, Wigley FM, Zaiman A, Champion HC, Hassoun PM, and Girgis RE.  Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. Arthritis Rheum 2009; 60:569-77.
  10. Mathai SC, Bueso M, Hummers LK, Boyce D, Lechtzin N, LePavec J, Ezquibela AC, Champion HC, Housten T, Forfia PR, Zaiman AL, Wigley FM, Girgis RE, Hassoun PM. Disproportionate elevation of NT-proBNP in scleroderma-related pulmonary hypertension. Eur Respir J 2010; 35:94-104.
  11. Campo AE, Mathai SC, Zaiman AL, Boyce D, Champion HC, Le Pavec J, Hummers LK, Lechtzin N, Wigley FM, Girgis RE, Hassoun PM. Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension. Am J Respir Crit Care Med 2010; 182:252-260.
  12. Le Pavec J, Girgis RE, Lechtzin N, Mathai SC, Launay D, Hummers LK, Zaiman A, Sitbon O, Simonneau G, Humbert M, Hassoun PM. Systemic sclerosis related pulmonary hypertension associated with interstitial lung disease: Impact of pulmonary arterial hypertension therapies. Arthritis Rheum 2011; 63:2456-64.
  13. Mathai SC, Sibley CT, Forfia PR, Mudd JO, Fisher MR, Tedford RJ, Lechtzin N, Boyce D, Hummers LK, Housten T, Zaiman AL, Girgis RE, Hassoun PM.  Tricuspid annular plane systolic excursion is a robust outcome measure in scleroderma-associated pulmonary arterial hypertension. J Rheum 2011; 38:2410-8.
  14. Mathai SC. The Wisdom of the PHAROS. J Rheum 2011; 38:2089-2091.
  15. Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA.  Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation 2012;125:289-97.
  16. Said Q, Martin BC, Joish VN, Kreilick C, Mathai SC. The cost to managed care of managing pulmonary hypertension. J Med Econ 2012; 15:500-8.
  17. Cheadle C, Berger AE, Mathai SC, Grigoryev DN, Watkins T, Sugawara Y, Barkataki S, Fan J, Boorgula M, Hummers LK, Zaiman AL, Girgis RE, McDevitt MA, Johns RA, Wigley FM, Barnes KC, Hassoun PM. Erythroid-specific transcriptional changes in PBMCs from pulmonary hypertension patients. PLoS One 2012; 7:e34951.
  18. Skrok J, Shehata ML, Mathai SC, Girgis RE, Zaiman A, Mudd JO, Boyce D, Lechtzin N, Lima JS, Bluemke DA, Hassoun PM, Vogel-Claussen J. Pulmonary arterial hypertension: MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiac function, and ventricular remodeling. Radiology 2012;263:678-87.
  19. Mathai SC, Puhan MA, Lam D, Wise RA. The minimal important difference in the six minute walk test for patients with pulmonary arterial hypertension. Am J Respir Crit Care Med 2012;186:428-33.
  20. Shehata ML, Harouni AA, Skrok J, Basha TA, Boyce D, Lechtzin N, Mathai SC, Girgis RE, Osman NF, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J. Regional and global biventricular function in pulmonary arterial hypertension: A cardiac MR imaging study. Radiology 2013;266:114-22.
  21. Yarmus Y, Akulian J, Gilbert C, Mathai SC, Sahetya S, Harris K, Gillespie C, Hass A, Feller-Kopman D, Sterman D, Lee HJ. Comparison of moderate vs. deep sedation for endobronchial ultrasound transbronchial needle aspiration. Ann Am Thorac Soc 2013 (accepted).
  22. Mathai SC. Solvitur Ambulando…or Maybe Not? Chest 2013; in press
  23. Tedford RJ, Mudd, JO, Girgis RE, Mathai SC, Zaiman AL, Housten-Harris T, Boyce D, Shah AA, Hummers LK, Wigley FM, Russell SD, Saggar R, Saggar R, Hassoun PM, Kass DA.  Right ventricular dysfunction in systemic sclerosis associated pulmonary arterial hypertension. Circ Heart Fail 2013 (in press).
  24. Khanna D, Gladue H, Channick R, Chung L, Distler O, Furst DE, Humbert M, Langleben D, Mathai SC, Saggar R, Visovatti S, Altorok N, Townsend W, Fitzgerald J, McLaughlin VV. Recommendations for screening and detection of connective-tissue disease associated pulmonary arterial hypertension. Arthritis Rheum 2013 (accepted).
  25. Blanco I, Mathai SC, Boyce D, Kolb TM, Chami H, Hummers LK, Housten T, Chaisson N, Zaiman AL, Wigley FM, Tedford RJ, Kass DA, Damico RL, Girgis RE, Hassoun PM. Severity of scleroderma-associated pulmonary arterial hypertension in African Americans. Under review.
  26. Bonner N, Abetz L, Meunier J, Sikirica M, Mathai SC. Development and validation of the Living with Pulmonary Hypertension Questionnaire in pulmonary arterial hypertension patients. Under review.

Invited Review Articles

  1. Mathai SC, Girgis RE. Pulmonary hypertension related to respiratory disease. Clinical Pulmonary Medicine 2007.
  2. Girgis RE, Mathai SC.  Pulmonary hypertension associated with chronic respiratory disease.  Clin Chest Med. 2007; 28(1):219-232.
  3. Mathai SC, Hassoun PM.  Treatment of pulmonary arterial hypertension. Hospital Physician Board Review Manual 2008.
  4. Mathai SC, Hassoun PM. The role of echocardiography in the diagnosis and assessment of pulmonary hypertension. Journal of the Pulmonary Hypertension Association Spring 2009.
  5. Mathai SC, Hassoun PM.  Therapy for scleroderma-related pulmonary arterial hypertension. Curr Opin Rheum 2009; 21:642-648.
  6. Le Pavec J, Launay D, Mathai SC, Hassoun PM, Humbert M. Scleroderma lung disease. Clin Rev Allergy Immunol 2011; 40:104-16.
  7. Boueiz A, Mathai SC, Hummers LK, Hassoun PM. Cardiac complications of systemic sclerosis:recent progress in diagnosis. Curr Opin Rheumatol 2010; 22:696-703.
  8. Mathai SC, Hassoun PM. Pulmonary hypertension associated with systemic sclerosis. Expert Rev Respir Med 2011;5:267-79.
  9. Mathai SC, Hassoun PM. Pulmonary arterial hypertension in connective tissue diseases. Heart Fail Clin 2012;8:413-25.
  10. Mathai SC, Girgis RE. Pulmonary hypertension topics. Expert Rev Respir Med 2012;6:503-5.
  11. Dezube R, Housten T, Mathai SC. Post-operative care of the patient with pulmonary hypertension. Advances in Pulmonary Hypertension. Fall 2013.

Extramural Sponsorship: Current

Dates 07/01/09-06/30/14
Title The Neurohormonal Axis in Scleroderma-Related Pulmonary Arterial Hypertension
Number K23
Sponsor NIH
Total Direct Cost $875,000
Principal Investigator Mathai
Role Principal Investigator, 75% effort
The major goals of this project are to describe the differences in neurohormonal response to pulmonary hypertension between patients with idiopathic and scleroderma-related pulmonary arterial hypertension using multiple modalities including serum markers and genetics and to determine whether these differences explain the worse survival in scleroderma-related pulmonary arterial hypertension

 

Dates 07/01/09-06/30/14
Title The Neurohormonal Axis in Scleroderma-Related Pulmonary Arterial Hypertension
Number K23
Sponsor Pulmonary Hypertension Association
Total Direct Cost $312,500
Principal Investigator Mathai
Role The major goals of this project are to describe the differences in neurohormonal response to pulmonary hypertension between patients with idiopathic and scleroderma-related pulmonary arterial hypertension and to determine whether these differences explain the worse survival in scleroderma-related pulmonary arterial hypertension.

EDUCATIONAL ACTIVITIES

Book Chapters

  1. Mathai SC. Using Respiratory Waveforms to Adjust Ventilator Settings. In: Handbook of Critical Care. Hogarth K, Hall JB, Schmidt GA, Wood LDH. McGraw-Hill; 2007. p. 289-292.

Other Media

  1. Mathai SC, Tuder RM, Hassoun PM. An 18-year old woman with severe dyspnea, hypoxia, and abnormal chest findings. American Thoracic Society Clinical Cases. www.thoracic.org/sections/clinical-information/ats-clinical-cases. June 2009.
  2. Mathai SC. What is Cystic Fibrosis? Johns Hopkins University Cystic Fibrosis Program. Website. June 2005.
  3. McCormack MC, Mathai SC, Caruso J, Claves J, Mangione S, and Kane GC. Resident as Teacher: Developing Skills for Bedside Teaching on Ward Rounds. Video Production. Thomas Jefferson University Hospital Department of Medicine. May 2001.

Teaching

2000-2003 National Youth Leadership Forum Speaker, Jefferson Medical College
2001-2003 Alpha Omega Alpha Student Lecture Series Speaker, Jefferson Medical College
2002-2003 Instructor, Code Blue Patient Simulator, Jefferson Medical College
2002-2003 Facilitator, Daily Internal Medicine Morning Report, Jefferson Medical College
2002-2003 Instructor of Physical Diagnosis, Jefferson Medical College
2005-2006 Instructor, Management of Sepsis Module; Physiology Course, Johns Hopkins University School of Medicine
2006-2007 Instructor, Patient, Physician, and Society, Johns Hopkins University School of Medicine
2006-2007 Director, IPF Patient Education Day, Johns Hopkins University School of Medcine
2011- Barker Firm Faculty
The Johns Hopkins Osler Residency Program
Medical Student Teaching Attending November-December 2011
Housestaff Teaching Attending January-February 2013
2012- Carol Johns Service
Section Leader, Pulmonary Hypertension Education
2012- Instructor, Genes to Society Course, Johns Hopkins School of Medicine
Pulmonary Vascular Disease Section

Mentoring: Pre-Doctoral

2009 Kaitlin Kroenig
Minority Summer Student Program
Current Position: Sales Representative Pharmaceutical Industry
2010 Calvin Walker
Minority Summer Student Program
2011 Andrea Yonge
Minority Summer Student Program
Current Position: Medical Student, Johns Hopkins University School of Medicine
2012 Kimberly Shao
Minority Summer Student Program
Current Position: 4th Year Student, University of Delaware

Mentoring: Post-Doctoral

2008-2010 Jerome LePavec, MD PhD
Visiting Post-Doctoral Fellow, Division of Pulmonary and Critical Care Medicine
Research Theme: Pulmonary hypertension in scleroderma-related interstitial lung disease
Current position: Faculty, Center National de Reference de l’Hypertension Pulmonaire Severe. Paris, France
2008-2010 Arantza Campo, MD
Visiting Post-Doctoral Fellow, Division of Pulmonary and Critical Care Medicine
Research Theme: Hemodynamic characterization of scleroderma-related pulmonary arterial hypertension
Current position: Faculty, Department of Pulmonology, University of Navarra. Navarra, Spain
2009- Monica Bueso, MD
Post-Doctoral Fellow, Division of Pulmonary and Critical Care Medicine
Research Theme: Outcome Measures in Scleroderma-related pulmonary arterial hypertension
Current position: Post-Doctoral Fellow, Division of Pulmonary and Critical Care Medicine
2011- Neal Chaisson, MD
Post-Doctoral Fellow, Division of Pulmonary and Critical Care Medicine
Research Theme: Echocardiography in the assessment of pulmonary arterial hypertension
Current position: Post-Doctoral Fellow, Division of Pulmonary and Critical Care Medicine
2012- Tomeka Suber, MD PhD
Osler Residency Housestaff
Research Theme: Quality of Life in Pulmonary Hypertension
Current position: Osler Residency Housestaff
2013- Majid Shafiq, MD
Attending hospitalist
Research Theme: Interstitial Lung Disease in Scleroderma-related Pulmonary Hypertension
Current Position: Assistant Professor of Medicine, Johns Hopkins University

Educational Program Building/Leadership

2011-present Organizer, Physiology Interest Group, Johns Hopkins University School of Medicine

CLINICAL ACTIVITIES

Certification

Maryland, 2004-current, D0060811
Pennsylvania, 1999-2004

Board Certification

2010- American Board of Internal Medicine, Critical Care Medicine
2009- American Board of Internal Medicine, Pulmonary Medicine
2002-2012 American Board of Internal Medicine Diplomate
1999- Basic Life Support
1999- Advanced Cardiac Life Support

Clinical Service Responsibilities

2008-present Pulmonary/Critical Care Medicine, Attending Physician, Johns Hopkins University School of Medicine, 6-8 weeks/year
2008-present Pulmonary Hypertension Clinic, Attending Physician, Johns Hopkins Outpatient Center, one-half day/week

ORGANIZATIONAL ACTIVITIES

Institutional Administrative Appointments

1990-1994 President of the Class of 1994, Rutgers College
1995-1999 Jefferson Medical College Student Council Representative
1997-1998 Jefferson Medical College Admissions Committee Speaker
1999-2000 Thomas Jefferson University Hospital Housestaff Council Member
2000-2001 Treasurer, Thomas Jefferson University Hospital Housestaff Association
2000-2001 Search Committee Member, Dean of Jefferson Medical College
2001-2002 President, Thomas Jefferson University Hospital Housestaff Association
2002-2003 Thomas Jefferson University Medical Grand Rounds Coordinator
2002-2003 Department of Medicine Steering Committee Member, Thomas Jefferson University Hospital
2002-2003 Attending-Resident Workflow Taskforce Chairperson, Thomas Jefferson University Hospital
2002-2003 Pharmacy and Therapeutics Committee, Thomas Jefferson University Hospital
2002-2003 Clinical Informatics Committee, Thomas Jefferson University Hospital
2002-2003 Acute Coronary Syndrome Clinical Pathway Committee, Thomas Jefferson University Hospital
2002-2003 Department of Medicine Liaison to Emergency Department, Thomas Jefferson University Hospital

Editorial Activities

Journal Peer Reviewer

2006-present Chest
2007-present Cardiology
2007-present Clinical Rheumatology
2008-present European Respiratory Journal
2008-present International Journal of Clinical Practice
2008-present American Journal of Respiratory and Critical Care Medicine
2009-present Journal of Rheumatology
2010-present Journal of the American College of Cardiology
2010-present Arthritis and Rheumatism
2010-present Seminars in Arthritis and Rheumatism
2011-present International Journal of Heart-Lung Transplant

Editorial Board

2011-2012 Editorial Advisor, Pulmonary Hypertension Reviews
2012-present Senior Editor, Pulmonary Hypertension Reviews
2013-present European Respiratory Journal

Advisory Committees, Review Groups / Study Sections

2009-2011 American Thoracic Society Clinical Problems Website Improvement Committee
2010 Biennial Conference Committee, Pulmonary Hypertension Association
2011-present Steering Committee, Pulmonary Vascular Disease Network, American College of Chest Physicians
2012-present PH Care Centers Committee, Pulmonary Hypertension Association
2012-present Reviewer, Chest Foundation Pulmonary Hypertension Award
2012 Scleroderma Foundation/Pulmonary Hypertension Association, Committee for Screening Recommendations for Pulmonary Hypertension in Connective Tissue Diseases
2012-2013 Program Committee, Pulmonary Circulation, American Thoracic Society
2012-2013 Database Committee, International Society of Heart-Lung Transplant
2012-present National Chairperson, Preceptorship Program, Pulmonary Hypertension Association
2013-2015 Scientific Leadership Council, Pulmonary Hypertension Association

Professional Societies

  • American Medical Association
  • American Thoracic Society
  • American College of Chest Physicians
  • European Respiratory Society
  • Society of Critical Care Medicine
  • International Society of Heart-Lung Transplantation
  • Pulmonary Vascular Research Institute
  • Pulmonary Hypertension Association

Conference Organizer, Session Chair

2006-2007 Organizer, “Life with Pulmonary Fibrosis”, Patient Education Day, Johns Hopkins Bayview Medical Center (3 sessions)
2009 Co-Chair, “Right Ventricular Function and Exercise”  Poster Discussion session, American Thoracic Society International Meeting, San Diego, CA
2013 Organizer/Session Chair, “The Right Ventricle in Health, Exercise, and Disease”, Post-graduate course, American Thoracic Society International Meeting, Philadelphia, PA
2013 Co-Chair, “Clinical Outcomes in Pulmonary Hypertension” Poster Discussion session. American Thoracic Society International Meeting, Philadelphia, PA

RECOGNITION

Awards and Honors

1994 Commencement Speaker, Rutgers College
1997-1999 Hobart Amory Hare Honor Medical Society
1997-1998 Foerderer Scholarship for International Study
2000 Thomas Jefferson University Intern of the Year Award
2001-present Alpha Omega Alpha Honor Medical Society
2001 Thomas Jefferson University Resident Teaching Award
2005-2007 Chest Foundation Clinical Research Trainee Award
2005 NIH Loan Repayment Award for Clinical Research
2007 First Prize Research Poster, Maryland Thoracic Society
2008 National Institutes of Health Loan Repayment Program-Renewal
2009 American College of Chest Physicians Leadership Development Program
2010 National Institutes of Health Loan Repayment Program- 2nd Renewal
2012 National Institutes of Health Loan Repayment Program-3rd Renewal
2012 Pulmonary Hypertension Association-Research Abstract Winner
2013 Scientific Leadership Council, Pulmonary Hypertension Association

Invited Talks, Panels

Local/Institutional

2003 Graduate Medical Education at Jefferson: Past, Present, and Future, Thomas Jefferson University Grand Rounds.  Philadelphia, PA
2007 Treatment of Pulmonary Hypertension, Maryland Society of Health System Pharmacists Annual Meeting. Columbia, Maryland
2007 Pulmonary Hypertension and Interstitial Lung Disease, Life with Pulmonary Fibrosis Conference.
Baltimore, Maryland
2007 Non-Invasive Assessment of Pulmonary Arterial Hypertension, Evolving Concepts in Pulmonary Hypertension Conference. Baltimore, Maryland
2007 Um Cahn Buree, Pulmonary Grand Rounds, Johns Hopkins University School of Medicine
2008 An Acute Case of Bad Handwriting, Pulmonary Grand Rounds, Johns Hopkins University School of Medicine
2008 Treatment of Pulmonary Hypertension: For Whom? With What?  Johns Hopkins Hospital Pharmacy Department Grand Rounds. Baltimore, Maryland
2008 ICU Management of Pulmonary Hypertension, Respiratory Care Conference, Johns Hopkins Bayview Medical Center. Baltimore, Maryland
2008 Non-Invasive Assessment of Pulmonary Arterial Hypertension, Osler Residency Noon Conference, Baltimore, MD
2008 Pulmonary Hypertension Overview, Internal Medicine Residency Noon Conference, Johns Hopkins Bayview Medical Center, Baltimore, MD
2009 Pulmonary Hypertension in 2009, Osler Residency Noon Conference, Baltimore, MD
2010 Diagnosis and Assessment of PH, Pulmonary Hypertension Association Preceptorship Program
University of Maryland, Baltimore, Maryland
2010 Emergency Situations in Pulmonary Hypertension, Pulmonary Hypertension Association on the Road, Pulmonary Hypertension Association. Towson, Maryland
2010 Pulmonary Hypertension in 2010, Osler Residency Noon Conference, Baltimore, MD
2010 Different Strokes for Different Folks: The Right Ventricle in PAH, Medical Grand Rounds. Johns Hopkins University School of Medicine
2011 If She Floats Like a Duck…Pulmonary Grand Rounds, Johns Hopkins University School of Medicine
2012 If She Floats Like a Duck…Part 2 Pulmonary Grand Rounds, Johns Hopkins University School of Medicine

National

2006 Health-Related Quality of Life in Pulmonary Hypertension, American Thoracic Society Meeting. San Diego, CA
2006 Tricuspid Annular Plane Systolic Excursion Predicts Mortality in Pulmonary Arterial Hypertension Associated with Scleroderma, American College of Chest Physicians Meeting. Salt Lake City, UT
2008 Pulmonary Arterial Hypertension Associated with Scleroderma, Pulmonary Grand Rounds, Wake Forest University. Winston-Salem, NC
2008 Understanding Pulmonary Hypertension: The Basics, 8th International Pulmonary Hypertension Conference Pulmonary Hypertension Association. Houston, TX
2009 Pulmonary Hypertension and Interstitial Lung Disease, Sunrise Seminar Series, American Thoracic Society International Meeting. San Diego, CA
2011 Should I Treat This Patient’s Pulmonary Hypertension related to Interstitial Lung Disease?, American College of Chest Physicians Meeting. Oahu, HI
2011 Pulmonary Vascular Disease: Bete Noire of Scleroderma, Pulmonary Grand Rounds, University of California at Los Angeles, Los Angeles, CA
2012 A Tale of Two* Failures, Pulmonary Grand Rounds, University of Pennsylvania, Pennsylvania, PA
2012 Phenotyping the Right Ventricle in Pulmonary Hypertension, Wall Center Symposium, Stanford University, Palo Alto, CA
2012 The β-Adrenergic System and Scleroderma-Related Pulmonary Arterial Hypertension, 10th International Pulmonary Hypertension Association Scientific Sessions. Orlando, FL
2012 Diet and Exercise in Pulmonary Hypertension, Panel Chair, 10th International Pulmonary Hypertension Association Meeting. Orlando, FL
2012 Treatment of Pulmonary Arterial Hypertension, Panelist, 10th International Pulmonary Hypertension Association Meeting. Orlando, FL
2012 Pulmonary Hypertension in Interstitial Lung Disease Associated with Connective Tissue Disease, American College of Rheumatology Annual Meeting. Washington, DC
2012 Treatment Targets in Pulmonary Arterial Hypertension, Update in Pulmonary Arterial Hypertension: What’s New, What’s Now, American Thoracic Society, Post Graduate Course, San Francisco, CA
2013 A View from the Right: Insights into Pulmonary Arterial Hypertension from the Study of Scleroderma, Centricity Series, Hofstra-North Shore-Long Island Jewish Medical College. Manhasset, NY
2013 The Right Stuff: Determinants of Right Ventricular Function in Pulmonary Arterial Hypertension Related to Scleroderma, Pulmonary Grand Rounds, University of Pittsburgh Medical Center, Pittsburgh, PA
2013 The Pathophysiology of Right Ventricular Failure, American Thoracic Society, Post-Graduate Course, Philadelphia, PA
2013 Is Scleroderma-Related Pulmonary Arterial Hypertension a Distinct Phenotype?, 7th Annual Yale Pulmonary Hypertension Symposium, Milton, CT
2013 Pulmonary Vascular Disease: Bete Noire of Scleroderma, 7th Annual Yale Pulmonary Hypertension Symposium, Milton, CT

International

2005 The Addition of Sildenafil to Bosentan in the Treatment of Pulmonary Arterial Hypertension, American College of Chest Physicians. Montreal, Canada
2010 Disproportionate Elevation of NT-proBNP in Scleroderma-Related Pulmonary Arterial Hypertension, European Respiratory Society. Vienna, Austria
2010 Adaptation versus Maladaptation of the RV in PAH, Pulmonary Vascular Research Institute. Lisbon, Portugal
2010 Do Outcomes Differ Between Idiopathic and Scleroderma-related PAH? Pulmonary Vascular Research Institute. Lisbon, Portugal
2011 Different Strokes for Different Folks: The Right Ventricle in Pulmonary Arterial Hypertension, Pulmonary Grand Rounds, Center National de Reference de l’Hypertension Pulmonaire Severe, Hopital Antoine Beclere. Paris, France
2012 The Pathophysiology of Right Ventricular Failure, International Society for Heart-Lung Transplantation. Prague, Czech Republic

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