Ying Yu, MD, PhD
University of California at San Diego
Sponsor: Jason X.J. Yuan, MD, PhD
"Roles of TRPC6 Channel in Pulmonary Artery Smooth Muscle Cell Proliferation and Primary Pulmonary Hypertension"
Term: July 1, 2003 - June 30, 2005
Curriculum Vitae
Suzhou Medical College, Suzhou, China, M.D., 1990 Medicine
Showa University, Tokyo, Japan, Ph.D., 1998 Physiology/Immunology
University of California, San Diego, Post-doc, 1999-2005 Physiology
Positions and Employment
1989-90 Intern, Changzhou General Hospital, Changzhou, China
1990-93 Research Assoc., Dept. of Radiobiological Effects, China Inst. for Radiation Protection, China
1999 Staff Scientist, Research Center for Genetic Engineering and Cell transplantation, School of Medicine, Tokai Univ., Japan.
1999-05 Postgraduate Researcher, Dept. of Medicine, University of California, San
Diego
2005- Assistant project scientist, Dept. of physiology & Biophysics, University of
California, Irvine
Honors and Awards
1993 Science Progress Award, Ministry of Nuclear Industry, China
1993-94 Scholarship, Showa University for International Student, Japan
1995-96 Honors Scholarship, Japan-China Medical Association, Japan
1997-99 Honors Scholarship, Association of International Education, Japan
2003-05 Pulmonary Hypertension Association Fellowship Award
Other Published Articles
Peer-reviewed articles (selected from 28 peer-reviewed articles, 1 book chapter, # as co-first author)
Yeromin A.V., Zhang, S.L., Jiang W., Yu, Y., Safrina, O., and Cahalan, M.D. (2006) Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature, in press
Zhang, S.L., Yeromin A.V., Zhang, X.H., Yu, Y., Safrina, O., Penna, A., Roos, J., Stauderman K.A. and Cahalan, M.D. (2006) Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity. PNAS. 103(24):9357-62.
Platoshyn, O., Brevnova, E., Burg, E., Yu, Y., Remillard, C. and Yuan, J.X. (2006) Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Am. J. Physiol. Cell. Physiol. 290, C907-C916
Zhang, S.L., Yu, Y., Roos, J., Kozak, J.A., Deerinck, T.J., Ellisman M.H., Stauderman K.A. and Cahalan, M.D. (2005) STIM1 is a Ca2+ sensor that migrates from the Ca2+ store to the plasma membrane to activate CRAC channels. Nature, 437, 902-5.
Kunichika, N., Landsberg, J.W., Yu, Y., Kunichika, H., Thistlethwaite, P.A., Rubin, L.J. and Yuan, J.X. (2004) Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am. J. Respir. Crit. Care Med. 170, 1101-7.
Kunichika, N., Yu, Y., Remillard, C.V., Platoshyn O., Zhang, S., and Yuan, J.X. (2004) Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L962-9.
Yu, Y., Sweeney, M., Zhang, S., Platoshyn, O., Landsberg, J.W., Rothman, A., and Yuan, J.X. (2003) PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am. J. Physiol. Cell. Physiol. 284: C316-30.
#Sweeney, M., Yu, Y., Platoshyn, O., Zhang, S., McDaniel, S.S., and Yuan, J.X. (2002) Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L144-55.
Gansuvd, B., Hagihara, M., Yu, Y., Inoue, H., Ueda, Y., Tsuchiya, T., Masui, A., Ando, K., Nakamura, Y., Munkhtuvshin, N., Kato, S., Thomas, J.M., and Hotta, T. (2002) Human umbilical cord blood NK T cells kill tumors by multiple cytotoxic mechanisms. Hum. Immunol. 63:164-75.
Yu, Y., Hagihara, M., Ando, K., Gansuvd, B., Matsuzawa, H., Tsuchiya, T., Ueda, Y., Inoue, H., Hotta,T., and Kato, S. (2001) Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. J. Immunol. 166: 1590-600.
#Platoshyn, O., Yu, Y., Golovina, V.A., McDaniel, S.S., Krick, S., Li, L., Wang, J.Y., Rubin, L.J., and Yuan, J.X. (2001) Chronic hypoxia decreases KV channel expression and function in pulmonary artery myocytes. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L801-12.
#Ekhterae, D., Platoshyn, O., Krick, S., Yu, Y., McDaniel, S.S., and Yuan, J.X. (2001) Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 281: C157-65.
Limsuwan, A., Platoshyn, O., Yu, Y., Rubin, L.J., Rothman, A., and Yuan, J.X. (2001) Inhibition of K+ channel activity in human pulmonary artery smooth muscle cells by serum from patients with pulmonary hypertension secondary to congenital heart disease. Pediatr. Res. 50: 23-8.
McDaniel, S.S., Platoshyn, O., Yu, Y., Sweeney, M., Miriel, V.A., Golovina, V.A., Krick, S., Lapp, B.R., Wang, J.Y., and Yuan, J.X. (2001) Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells. J. Appl. Physiol. 91: 2322-33.
McDaniel, S.S., Platoshyn, O., Wang, J., Yu, Y., Sweeney, M., Krick, S., Rubin, L.J., and Yuan, J.X. (2001) Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L870-80.
Yu, Y., Kasahara, T., Sato, T., Asano, K., Yu, G., Fang, J.Q., Guo, S.Y., Sahara, M., and Hisamitsu, T. (1998) Role of endogenous interferon-gamma on the enhancement of splenic NK cell activity by electroacupuncture stimulation in mice. J Neuroimmunol. 90: 176-86.
Asano, K., Matsuishi, J., Yu, Y., Kasahara, T., and Hisamitsu, T. (1998) Suppressive effects of Tripterygium wilfordii Hook f., a traditional Chinese medicine, on collagen arthritis in mice. Immunopharmacology 39: 117-26.
Asano, K., Yu, Y., Kasahara, T., and Hisamitsu, T.(1997) Inhibition of murine chronic graft-versus-host disease by the chloroform extract of Tripterygium wilfordii Hook f.Transpl Immunol. 5: 315-9.
Yu, Y., Kasahara, T., Sato, T., Guo, S.Y., Liu, Y., Asano, K., and Hisamitsu, T. (1997) Enhancement of splenic interferon-gamma, interleukin-2, and NK cytotoxicity by S36 acupoint acupuncture in F344 rats. Jpn. J. Physiol. 47: 173-8.
Sato, T., Yu, Y., Guo, S.Y., Kasahara, T., and Hisamitsu, T. (1996) Acupuncture stimulation enhances splenic natural killer cell cytotoxicity in rats. Jpn. J. Physiol. 46: 131-6.
Invited Articles, Book Chapters
Yu, Y., Platoshyn, O., and Yuan, J.X. (2005) Correlation of ion channel activity with gene expression using single-cell RT-PCR and patch clamp techniques: Ion Channels in the Pulmonary Vasculature; Marcel Dekker, New York, NY.
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Ying Yu, MD, PhD
