PHA/AHA Post Doctoral Fellowship Award Winner 2002

Hideyuki Beppu, MD, PhD Hideyuki Beppu, MD, PhD

Massachusetts General Hospital
Sponsor: En Li, PhD
"The Genetic Basis of PH - Studies in Genetically Modified Mice"
Term: July 1, 2002 - June 30, 2004

Summary of Research Project:

The Genetic Basis of PH - Studies in Genetically Modified Mice

We have been studying the functional role of BMP type II receptor (BMPR2) using the genetically modified mice of BMPR2. Our goal is to generate the mouse model of primary pulmonary hypertension, and to investigate the molecular mechanism to understand the pathogenesis of the pulmonary hypertension.

Curriculum Vitae

  • 1988-1994: School of Medicine, Kagoshima University (Japan)
  • 1994: MD
  • 1995-1999: Department of Biochemistry, Cancer Institute, Tokyo, Japan (Supervised by Prof. Kohei Miyazono)
  • 1998: PhD
  • 1999-2004: Postdoctoral reseach fellow, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School (Supervised by Drs. En Li and Kenneth D. Bloch)
  • 2004-Present: Instructor in Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School

Other Published Articles

  • Song, Y., Jones, J. E., Beppu, H., Keaney, J. F., Jr., Loscalzo, J., Zhang, Y. Y. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 2005; 112:553-562.
  • Yu, P. B., Beppu, H., Kawai, N., Li, E., Bloch, K. D. BMP type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem 2005; 280:24443-24450.
  • Beppu, H., Lei, H., Bloch, K. D. Li, E. Generation of a floxed allele of the mouse BMP type II receptor gene. Genesis 2005; 41;133-137.
  • Beppu, H., Ichinose, F., Kawai, N., Jones, R. C., Yu, P. B., Zapol, W. M., Miyazono, K., Li, E. Bloch, K. D. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol 2004; 287:L1241-1247.

FacebookTwitterInstagram iconLinkedInYouTube

For optimal viewing of, please use a standards-compliant browser such as Google Chrome or Firefox.

The information provided on the PHA website is provided for general information only. It is not intended as legal, medical or other professional advice, and should not be relied upon as a substitute for consultations with qualified professionals who are familiar with your individual needs. PHA does not endorse or recommend any commercial products or services.

801 Roeder Road, Ste. 1000, Silver Spring, MD 20910   Patient-to-Patient Support Line: 1-800-748-7274
    Privacy Policy    Terms of Use    Provide Feedback & Report Bugs

Designed by Matrix Group International, Inc.® | © 2017 Pulmonary Hypertension Association. All Rights Reserved.

BBB Accredited Charity BEST in AmericaCharity Navigator

The National Organization for Rare Disorders (NORD) awarded PHA the Abbey S. Meyers Leadership Award in 2012 for outstanding service to PHA members in advocacy, education and other key areas.